ArticleBiomolecules2026
CFTR and ClC-3 Transport Fluoride Differently and Cause Dental Fluorosis in Different Ways.
Yanli Zhang, Songya Mao, Xuan Wen, Zhenxia Liu, Ying Hao, Xiaohong Duan
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In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
Yanli ZhangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Songya MaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0009-0002-6156-7775 Xuan WenState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Zhenxia LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Ying HaoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.
Xiaohong DuanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Disease, Shaanxi Key Laboratory of Stomatology, Department of Oral Biology, Clinic of Oral Rare Diseases and Genetic Diseases, School of Stomatology, The Fourth Military Medical University, Xi'an 710032, China.ORCID 0000-0002-6747-1734 Funding
Natural Science Foundation of China 82370907, 82100958, 81771052, 81070819
6 · The paper itselfAbstract
Dental fluorosis (DF) is a common endemic disease that damages dental enamel. Traditionally, DF has been attributed to environmental fluoride overload. Accumulating evidence has demonstrated that genetic factors also modulate individual susceptibility. No dedicated fluoride ion channels have been identified in mammalian cells; fluoride uptake is believed to occur mainly through passive diffusion of HF and nonspecific anion pathways, including chloride channels. Different types of chloride channels are expressed in dental tissues, such as CFTR and voltage-gated chloride channels (ClCs), but it remains unknown whether these channels transport fluoride and whether their variants influence DF risk. This study combined human population-based investigations, mouse and zebrafish models, and in vitro experiments to confirm the significant genetic association of
Indexed as
Chloride ChannelsCystic Fibrosis Transmembrane Conductance RegulatorFluoridesFluorosis, DentalAnimalsFemaleHumansMicePolymorphism, Single NucleotideZebrafishCFTR protein, humanChloride ChannelsClC-3 channelCystic Fibrosis Transmembrane Conductance RegulatorFluoridesCFTRchlorideClC-3dental fluorosisfluoridegenetic
Identifiers
PMID42509776
PMCPMC13406507
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