Evidence map›Paper›PMID 42509764›Full record

ArticleBiomolecules2026

Understanding the Role of Macrocycle Size and Amide Linkage in Teixobactin Analogues.

Ruba Malkawi, James Weldon-Bee, Edwin Kiptoo, Sanjit Das, Yinzhe Chen, Abhishek Iyer, Rajamani Lakshminarayanan, Qian Zhang, Anish Parmar, Ishwar Singh

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruba MalkawiAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0001-9025-6752
James Weldon-BeeAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.
Edwin KiptooAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0009-0004-2459-7224
Sanjit DasAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.
Yinzhe ChenAntimicrobial Pharmacodynamics and Therapeutics, Department of Pharmacology and Therapeutics, Institute of Systems, Molecular & Integrative Biology, University of Liverpool, William Henry Duncan Building, 6 West Derby St., Liverpool L7 8TX, UK.
Abhishek IyerSchool of Pharmacy, University of Lincoln, JBL Building, Beevor St., Lincoln LN6 7DL, UK.
Rajamani LakshminarayananSingapore Eye Research Institute, Singapore 169857, Singapore.ORCID 0000-0001-8214-5315
Qian ZhangAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.
Anish ParmarAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.
Ishwar SinghAntimicrobial Drug Discovery and Development, The Robert Robinson Laboratories, Department of Chemistry, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0001-7822-1063

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Teixobactin is a promising antibiotic that targets cell wall biosynthesis in Gram-positive bacteria and displays a low propensity for resistance; however, its structural complexity presents challenges for analogue development and optimisation. In this study, we investigated the effects of macrocycle size and replacement of the native depsipeptide linkage with an amide bond on antibacterial activity using a simplified Leu

Indexed as

AmidesAnti-Bacterial AgentsDepsipeptidesMacrocyclic CompoundsMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsStructure-Activity RelationshipAmidesAnti-Bacterial AgentsDepsipeptidesMacrocyclic Compoundsteixobactinantimicrobial peptidescyclic peptidesmacrocycle expansionmacrolactamisationmethicillin-resistant Staphylococcus aureus (MRSA)solid-phase peptide synthesisteixobactin

Identifiers

PMID42509764
PMCPMC13406156

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.