Evidence map›Paper›PMID 42509743›Full record

ArticleBiomolecules2026

Real-Time Fibrinolysis Monitoring of Plasma Annular Clots.

Andres Prieto Trujillo, Anushri Umesh, Abigail Hall, Nathan J Alves

Abstract read
In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andres Prieto TrujilloDepartment of Emergency Medicine, Indiana University School of Medicine, 635 Barnhill Dr. Rm. 2063, Indianapolis, IN 46202, USA.ORCID 0000-0003-1732-9681
Anushri UmeshDepartment of Emergency Medicine, Indiana University School of Medicine, 635 Barnhill Dr. Rm. 2063, Indianapolis, IN 46202, USA.ORCID 0000-0002-8891-7766
Abigail HallDepartment of Emergency Medicine, Indiana University School of Medicine, 635 Barnhill Dr. Rm. 2063, Indianapolis, IN 46202, USA.
Nathan J AlvesDepartment of Emergency Medicine, Indiana University School of Medicine, 635 Barnhill Dr. Rm. 2063, Indianapolis, IN 46202, USA.ORCID 0000-0003-3816-5137

Funding

Modulating Fibrinolysis Dynamics by Leveraging Multivalent Avidity to Control Enzyme ActivityR01HL167877 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Nathan J Alves · 2023 to 2026
$1.9M
National Heart Lung and Blood Institute R01HL167877NHLBI NIH HHS R01 HL167877
6 · The paper itself

Abstract

Fibrinolysis assessment is critical for diagnosing and managing clinical blood disorders. Currently available viscoelastic testing platforms provide an overview of global coagulation and fibrinolysis profiles but lack fibrinolysis specific assessment of a preformed clot substrate. The lack of a sensitive, standardized testing platform for fibrinolysis assessment can limit risk stratification and the management of blood disorders. We describe herein the plasma annular clot lysis assay. The assay adapts the previously standardized FITC-tagged fibrin annular clot assay to plasma obtained from healthy human donors. Plasmin at concentrations ranging from 200-800 nM was used as a direct thrombolytic to assess fibrinolysis in plasma-derived annular clots. The Maximum Fibrinolysis Rate (V

Indexed as

FibrinolysisThrombosisBlood CoagulationFibrinFibrinolysinHumansPlasmaThrombelastographyFibrinFibrinolysinfibrinolysis assessmentfluorescenceplasma clotsthrombolytic therapy

Identifiers

PMID42509743
PMCPMC13406176

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.