Evidence map›Paper›PMID 42509740›Full record

ArticleBiomolecules2026

Identification of Ligand-Responsive RNA G-Quadruplexes in the 3' UTRs of Dengue Virus Serotypes.

Mohammad Jafar Sheikhi, Ayuka Onuma, Yutaro Imachi, Akira Shiraishi, Shoko Mori, Kohtaro Sugahara, Daisuke Miyoshi, Yue Ma, Takayuki Hishiki, Kazuo Nagasawa and 1 more

Abstract read
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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mohammad Jafar SheikhiDepartment of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Tokyo 184-8588, Japan.
Ayuka OnumaDepartment of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Tokyo 184-8588, Japan.
Yutaro ImachiDepartment of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Tokyo 184-8588, Japan.
Akira ShiraishiBioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.ORCID 0000-0003-3456-3074
Shoko MoriBioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.ORCID 0000-0002-9309-8005
Kohtaro SugaharaBioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1 Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan.
Daisuke MiyoshiFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe 650-0047, Japan.ORCID 0000-0002-4308-0499
Yue MaLaboratory for Biomaterials and Bioengineering, Institute of Science Tokyo, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Takayuki HishikiDepartment of Drug Development, National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo 162-8655, Japan.
Kazuo NagasawaDepartment of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Tokyo 184-8588, Japan.
Masayuki TeraDepartment of Biotechnology and Life Science, Faculty of Engineering, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Tokyo 184-8588, Japan.ORCID 0000-0003-4430-579X

Funding

Japan Agency for Medical Research and Development JP25ak0101271Japan Agency for Medical Research and Development JP25ak0101274Japan Science and Technology Agency JPMJSF2313Japan Society for the Promotion of Science 24K01623Japan Society for the Promotion of Science 24K21819Takeda Science Foundation Not appicable
6 · The paper itself

Abstract

Dengue virus (DENV), which comprises four antigenically distinct serotypes (DENV-1 to DENV-4), remains a major global public health concern and continues to expand geographically; however, the structural features of the viral genome remain incompletely understood. Although G-quadruplexes (G4s) have previously been reported in coding regions of DENV, their presence within the 3' untranslated region (3' UTR) has not been experimentally characterized. Here, we focused on selected guanine-rich motifs within the 3' UTRs of DENV-1 to DENV-4 and investigated their ability to form RNA G4 structures. Using bioinformatic analysis, we identified comparable G-rich regions in the 3' UTRs of the four serotypes, with serotype-dependent differences in conservation. We then examined the propensity of the selected putative quadruplex-forming sequences (PQSs) to adopt G4 structures using circular dichroism spectroscopy, UV melting analysis,

Indexed as

3' Untranslated RegionsDengue VirusG-QuadruplexesRNA, ViralBase SequenceLigandsNucleic Acid ConformationSerogroup3' Untranslated RegionsLigandsRNA, Viral3′ untranslated regiondengue viruspotential quadruplex-forming sequenceRNA G-quadruplexes

Identifiers

PMID42509740
PMCPMC13407133

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.