Evidence map›Paper›PMID 42509672›Full record

ArticleCell biochemistry and function2026

Synergistic Effect of Digoxin and Cisplatin on Redox Imbalance in HeLa Cells.

Duane Gischewski Pereira, Israel José Pereira Garcia, Graziele Aparecida Silva Maia, Jéssica Martins Moura de Valadares, Ana Carolina Pacheco Ramos, Herica Lima Santos, Silvana Gisele Pegorin de Campos, José Augusto Fp Villar, Leandro A Barbosa, Vanessa Faria Cortes

Abstract read
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In one paragraph

Article in Cell biochemistry and function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Duane Gischewski PereiraLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0001-8353-761X
Israel José Pereira GarciaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0002-4972-6561
Graziele Aparecida Silva MaiaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0001-8448-0002
Jéssica Martins Moura de ValadaresLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0002-9934-2793
Ana Carolina Pacheco RamosLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0003-3266-3717
Herica Lima SantosLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0001-8105-4980
Silvana Gisele Pegorin de CamposDepartment of Biological Sciences, IBIlCE, UNESP, Rua Cristovão Colombo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6813-7148
José Augusto Fp VillarLaboratório de Síntese Orgânica e Nanoestruturas, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0003-1580-0644
Leandro A BarbosaLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0002-4631-0130
Vanessa Faria CortesLaboratório de Bioquímica Celular, Universidade Federal de São João del-Rei, Campus Centro-Oeste Dona Lindú, Divinópolis, Brazil.ORCID https://orcid.org/0000-0002-6464-7634

Funding

Conselho Nacional de Desenvolvimento CientÍfico e TecnolÓgico 403646/2021-9Conselho Nacional de Desenvolvimento CientÍfico e TecnolÓgico 409119/2023-7Coordenação de AperfeiÇoamento de Pessoal de NÍvel Superior 001Financiadora de Estudos e Projetos 1640-22Fundação de Amparo À Pesquisa do Estado de Minas Gerais APQ-01915-22Fundação de Amparo À Pesquisa do Estado de Minas Gerais RED-00110-23
6 · The paper itself

Abstract

Our previous study demonstrated a potent synergistic antitumor effect between 1 nM digoxin and 1 μM cisplatin in cervical cancer cells, which was dependent on the modulation of the signaling pathway involving Na, K-ATPase/Src. Because of the relationship between Na, K-ATPase/Src and the modulation of oxidative stress, the aim of this study was to demonstrate the effect of combined treatment with digoxin and cisplatin on oxidative stress parameters in HeLa cells and the effect of treatment in non-tumor cell lines. Analysis of oxidative stress parameters revealed a significant reduction in cellular antioxidant defense mechanisms, SOD activity, and content of reduced total thiol groups. Additionally, there was an increase in H

Indexed as

Antineoplastic AgentsCisplatinDigoxinApoptosisCell SurvivalDrug SynergismHeLa CellsHumansLipid PeroxidationOxidation-ReductionOxidative StressSodium-Potassium-Exchanging ATPaseAntineoplastic AgentsCisplatinDigoxinSodium-Potassium-Exchanging ATPasecancer therapycisplatincombined treatmentdigoxinoxidative stress

Identifiers

PMID42509672
PMCPMC13408207

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.