Evidence map›Paper›PMID 42509437›Full record

ArticleBulletin of experimental biology and medicine2026

Does Microfluidic Sperm Sorting Affect Embryo Ploidy in Human In Vitro Fertilization?

N P Makarova, A A Seliverstova, I S Kichko, E N Ekimov, A P Sysoeva, M Yu Gavrilov, B V Zingerenko, E A Kalinina

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

N P MakarovaNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia. np.makarova@gmail.com.
A A SeliverstovaPeoples' Friendship University of Russia Named after Patrice Lumumba (RUDN University), Moscow, Russia.
I S KichkoNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
E N EkimovNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
A P SysoevaNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
M Yu GavrilovNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
B V ZingerenkoNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.
E A KalininaNational Medical Research Center of Obstetrics, Gynecology, and Perinatology Named after Academician V. I. Kulakov, Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The genetic status of embryos obtained during in vitro fertilization (IVF) programs using spermatozoa selected by microfluidic sorting was evaluated. Genetic testing was conducted on 127 embryos in the main group and 194 in the control group. The embryos were cultured under standard conditions; blastocyst biopsy was performed on day 5 for subsequent preimplantation genetic testing for aneuploidies using high-throughput sequencing. The use of microfluidic chips significantly increased the yield of blastocysts (p = 0.03) without affecting fertilization rates or embryo quality. However, when assessing the genetic status of embryos, no significant differences were found: the frequency of embryos with a normal karyotype was 29.9% in the main group and 32.4% in the control group (odds ratio, OR = 0.88). Microfluidic sperm sorting improves embryological parameters, particularly blastulation rates, but has no statistically significant effect on the genetic status of preimplantation human embryos, leaving this topic open for further investigation.

Indexed as

BlastocystFertilization in VitroPloidiesSpermatozoaAdultAneuploidyFemaleHumansMalePregnancyPreimplantation Diagnosisaneuploidyassisted reproductive technologiesmicrofluidic sperm sortingpreimplantation genetic testingsperm selection

Identifiers

PMID42509437

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.