ArticlePain and therapy2026
MR-107A-02 in Acute Postoperative Pain Management Following Bunionectomy: Results from a Multicenter, Placebo- and Active-Controlled, Phase 3 Trial.
Article in Pain and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06215820 (A Multi-Center, Randomized, Double-Blind, Placebo-), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Center, Randomized, Double-Blind, Placebo- (Double-Dummy) and Active-Controlled, Parallel-Group Study of MR-107A-02 for the Treatment of Acute Postoperative Pain Following Bunionectomy
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Authors and funding
8 authors.
Funding
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Abstract
introductionMR-107A-02 is a novel, fast-absorbing oral meloxicam formulation designed to deliver effective analgesia in moderate-to-severe acute pain settings.
methodsThis phase 3, randomized, double-blind, placebo- and active-controlled, parallel-group study assessed the efficacy and safety of MR-107A-02 in participants following bunionectomy. Participants with a postoperative pain numerical rating scale at rest (NRS-R) score ≥ 4 and a moderate or severe qualifying categorical pain score were randomized in a 1:1:1 ratio to receive MR-107A-02 15 mg (BID), placebo, or tramadol 50 mg (q6h). The primary endpoint was the summed pain intensity difference over 48 h (SPID
resultsOf the 410 randomized participants, 397 completed the study. Baseline NRS-R scores were similar across groups. MR-107A-02 met the primary endpoint, with a significantly greater SPID
conclusionsMR-107A-02 provided statistically significant analgesic efficacy, faster onset of action, good tolerability, and reduced opioid rescue medication compared with placebo, highlighting its opioid-sparing potential. These findings should be interpreted within the constraints of the bunionectomy model, and confirmation in broader surgical settings is warranted. CLINICAL
trial registrationClinicalTrials.gov identifier: NCT06215820.
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