Evidence map›Paper›PMID 42509336›Full record

ArticleNature nanotechnology2026

Spontaneous and indefinite blinking in upconverting nanoparticles for ångström-precision multicolour super-resolution imaging.

Saptarshi Mandal, Harrison W Toll, Kaibo Ma, Irmuun Tommy Altankhuyag, Lidao Li, Wanlin Zhang, João F Shida, Chunte Sam Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Saptarshi MandalBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2837-9895
Harrison W Toll *Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3653-2426
Kaibo Ma *Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0004-1415-0023
Irmuun Tommy AltankhuyagBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0005-5406-8742
Lidao LiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7341-3426
Wanlin ZhangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0002-9127-3559
João F ShidaBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7333-3274
Chunte Sam PengBroad Institute of MIT and Harvard, Cambridge, MA, USA. sampeng@mit.edu.ORCID http://orcid.org/0000-0001-8885-2619

Funding

Ultralong-term single-molecule imaging of amyloid precursor protein (APP) processing in Alzheimer's diseaseR00AG065516 · NIA · BROAD INSTITUTE, INC. · PI PENG, CHUNTE · 2023 to 2025
$722k
Alfred P. Sloan Foundation G-2024-22448NIA NIH HHS R00 AG065516U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging) 5R00AG065516-04
6 · The paper itself

Abstract

Single-molecule localization microscopy enables high-resolution biological imaging, but its precision is limited by the rapid photobleaching of conventional fluorophores. Multicolour imaging is further constrained by the need for spectrally distinct dyes requiring separate excitations or sequential acquisition. Here we show that small (~10 nm) upconverting nanoparticles can be compositionally tuned to exhibit spontaneous, sustained blinking under single near-infrared excitation without optical or chemical modulation. By adjusting sensitizer (Yb

Identifiers

PMID42509336
PMCPMC13569437

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.