Evidence map›Paper›PMID 42509302›Full record

ArticleNature aging2026

Systemic and local chronic inflammation and hormone disposition promote a tumor-permissive environment for breast cancer in older women.

Neil Carleton, Alexander Chih-Chieh Chang, Sanghoon Lee, Ruxuan Li, Jian Zou, Daniel D Brown, Jagmohan Hooda, Jian Chen, Rahul Kumar, Linda R Klei and 17 more

Abstract read
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Immuno-oncology recapitulates ontogeny: Modern cell and gene therapy for cancer.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors.

Neil CarletonWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Alexander Chih-Chieh ChangWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Sanghoon LeeWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-8564-2392
Ruxuan LiDepartment of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Jian ZouDepartment of Statistics, School of Public Health, Chongqing Medical University, Chongqing, China.
Daniel D BrownInstitute for Precision Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7410-9514
Jagmohan HoodaWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Jian ChenWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Rahul KumarWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Linda R KleiWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Lora H RigattiDivision of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joseph NewsomeDivision of Laboratory Animal Resources, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dixcy Jaba Sheeba John MaryWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Jennifer M AtkinsonWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Raymond E WestSmall Molecule Biomarker Core, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.
Thomas D NolinSmall Molecule Biomarker Core, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4339-1382
Patrick J OberlySmall Molecule Biomarker Core, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.
Ziyu HuangUPMC Hillman Cancer Center Biostatistics Facility, Pittsburgh, PA, USA.
Donald PoirierLaboratory of Medicinal Chemistry, CHU de Québec, Research Centre Université Laval, Quebec City, Quebec, Canada.
Emilia J DiegoDivision of Breast Surgical Oncology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Peter C LucasDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-4880-7172
George C TsengDepartment of Biostatistics, University of Pittsburgh School of Public Health, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-5447-1014
Michael T LotzeDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-3988-5419
Priscilla F McAuliffeWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Ioannis K ZervantonakisDepartment of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-2386-9553
Steffi OesterreichWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2537-6923
Adrian V LeeWomen's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA. leeav@upmc.edu.ORCID http://orcid.org/0000-0001-9917-514X

Funding

VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0M
Training in Cellular & Molecular Mechanisms of Tumor RejectionT32CA082084 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert J Binder, Dario AA Vignali · 1999 to 2026
$9.2M
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
API 4000 QTRAPS10RR023461 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI POLOYAC, SAMUEL M · 2007 to 2007
$487k
Small Molecule Biomarker Core: TSQ Altis LC-MS/MSS10OD028540 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NOLIN, THOMAS DOUGLAS · 2020 to 2020
$429k
Promotion of ER+ Breast Cancer Progression in the ElderlyF30CA264963 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARLETON, NEIL · 2021 to 2025
$243k
NCI NIH HHS F30 CA264963NCI NIH HHS P30 CA047904NCI NIH HHS T32 CA082084NCRR NIH HHS S10 RR023461NIH HHS S10 OD028483NIH HHS S10 OD028540U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P30CA047904
6 · The paper itself

Abstract

Estrogen receptor-positive (ER

Indexed as

AgingBreast NeoplasmsEstrogensInflammationTumor MicroenvironmentAgedAnimalsChemokine CCL2FemaleHumansMacrophagesRatsReceptors, EstrogenSignal TransductionChemokine CCL2EstrogensReceptors, Estrogen

Identifiers

PMID42509302
PMCPMC13472878

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.