ArticleLeukemia2026
Cohesin haploinsufficiency and inv(16) cooperate to reinforce Fli1 gene transcriptional programs during acute myeloid leukemia initiation and maintenance.
Alison E Meyer, Katelyn E Heimbruch, Kirthi Pulakanti, Cary Stelloh, Nataly Cruz-Rodriguez, Josiah Murray, Dandan Wang, Lisa Latzko, Sebastian Vosberg, Philipp A Greif and 4 more
Abstract read
In one paragraphArticle in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
14 authors.
Alison E Meyer *Versiti Blood Research Institute, Milwaukee, WI, USA.
Katelyn E Heimbruch *Pediatric Residency Program, Cincinnati Children's Hospital, Cincinnati, OH, USA.
Cary StellohVersiti Blood Research Institute, Milwaukee, WI, USA.
Nataly Cruz-RodriguezVersiti Blood Research Institute, Milwaukee, WI, USA.
Dandan WangVersiti Blood Research Institute, Milwaukee, WI, USA.
Philipp A GreifDepartment of Medicine III, University Hospital, LMU Munich, Munich, Germany.
John A PulikkanVersiti Blood Research Institute, Milwaukee, WI, USA.
Subramaniam MalarkannanVersiti Blood Research Institute, Milwaukee, WI, USA.
Funding
Sequencing Coordination and Data Analysis CoreP01HL149620 · NHLBI · UNIVERSITY OF ARIZONA · PI LIU, PENGYUAN · 2020 to 2024
$11.8MDefining GATA4’s Molecular Function in Gastric Cell BiologyR01DK134064 · NIDDK · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BATTLE, MICHELE A, RAO, SRIDHAR · 2022 to 2025
$2.1MCohesin Mutations in Acute Myelogenous LeukemiaR01CA204231 · NCI · VERSITI WISCONSIN, INC. · PI RAO, SRIDHAR · 2017 to 2021
$1.9MGATA2-TGF beta-TAL1 pathway as a critical mediator of NK Cell developmentR01AI183571 · NIAID · MEDICAL COLLEGE OF WISCONSIN · PI BARBARA L. KEE, Subramaniam Malarkannan · 2025 to 2026
$1.5MCohesin Mutations in Core-Binding Factor Acute Myeloid LeukemiaF30CA236322 · NCI · VERSITI WISCONSIN, INC. · PI HEIMBRUCH, KATELYN E · 2019 to 2022
$200kNCI NIH HHS F30 CA236322NCI NIH HHS R01 CA204231NHLBI NIH HHS P01 HL149620NIAID NIH HHS R01 AI183571NIDDK NIH HHS R01 DK134064U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA204231U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA236322U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL149620U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) DK134064
6 · The paper itselfAbstract
Core binding factor (CBF) acute myeloid leukemias typically harbor the translocations t(8;21) or inv(16). As cohesin mutations are less commonly observed with inv(16) than with t(8;21), we hypothesized that they may negatively impact inv(16)-driven AML. Using a mouse model of inv(16) with haploinsufficiency of the cohesin subunit Smc3, we paradoxically found that inv(16); Smc3
Indexed as
Cell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome InversionGene Expression Regulation, LeukemicHaploinsufficiencyLeukemia, Myeloid, AcuteProto-Oncogene Protein c-fli-1Transcription, GeneticAnimalsChondroitin Sulfate ProteoglycansCohesinsHematopoietic Stem CellsMiceCell Cycle ProteinsChondroitin Sulfate ProteoglycansChromosomal Proteins, Non-HistoneCohesinsFli1 protein, mouseProto-Oncogene Protein c-fli-1SMC3 protein, mouse
Identifiers
PMID42509256
PMCPMC13612242
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