Evidence map›Paper›PMID 42509248›Full record

ArticleNature communications2026

Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2.

Maximilian Sandmann, Sahra Tajdar, Simon Sander, David Ruiz Carrillo, Benedikt Ganter, Celine Fischer, Marina Ocenas, Stefanie Etzold, Neele Pekarek, Julia Berger and 11 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Maximilian SandmannDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0009-0004-5741-6629
Sahra TajdarOrganic Chemistry, Department of Chemistry, University of Hamburg, Hamburg, Germany.
Simon SanderThe Hamburg Advanced Research Center for Bioorganic Chemistry (HARBOR) & Department of Chemistry, Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7985-2526
David Ruiz CarrilloEuropean Molecular Biology Laboratory Hamburg, Hamburg, Germany.
Benedikt GanterOrganic Chemistry, Department of Chemistry, University of Hamburg, Hamburg, Germany.
Celine FischerOrganic Chemistry, Department of Chemistry, University of Hamburg, Hamburg, Germany.
Marina OcenasDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefanie EtzoldDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Neele PekarekInstitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Julia BergerInstitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0009-0005-5857-4386
Toni Luise MeisterBernhard Nocht Institute, Leibniz Institute for Tropical Medicine, Hamburg, Germany.ORCID http://orcid.org/0000-0001-8962-9443
Barbara SeliskoLaboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille Université, UMR7257, Marseille, France.
Bruno CanardLaboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), CNRS, Aix-Marseille Université, UMR7257, Marseille, France.ORCID http://orcid.org/0000-0003-4924-1991
Joanna M WattDepartment of Life Sciences, University of Bath, Bath, UK.
Ondřej BaszczyňskiDepartment of Life Sciences, University of Bath, Bath, UK.ORCID http://orcid.org/0000-0003-0195-9953
Barry Vl PotterDepartment of Life Sciences, University of Bath, Bath, UK.ORCID http://orcid.org/0000-0003-3255-9135
Maria Garcia AlaiEuropean Molecular Biology Laboratory Hamburg, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5200-7816
Henning TidowThe Hamburg Advanced Research Center for Bioorganic Chemistry (HARBOR) & Department of Chemistry, Institute for Biochemistry and Molecular Biology, University of Hamburg, Hamburg, Germany.
Susanne PfefferleInstitute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7489-6557
Chris MeierOrganic Chemistry, Department of Chemistry, University of Hamburg, Hamburg, Germany.
Ralf FliegertDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. r.fliegert@uke.de.ORCID http://orcid.org/0000-0002-4374-673X

Funding

Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Deutsche Forschungsgemeinschaft (German Research Foundation) 335447717Deutsche Forschungsgemeinschaft (German Research Foundation) 512741711Deutsches Zentrum für Infektionsforschung (German Center for Infection Research) TTU 01.719NIGMS NIH HHS P41 GM103311NIH HHS P41-GM103311Wellcome TrustWellcome Trust 101010
6 · The paper itself

Abstract

Enzymatically active macrodomains of (+)ss-RNA viruses mediate immune evasion by countering ADP-ribosylation and are therefore promising druggable targets. Here we report testing of ADP / ADP-ribose analogues for their ability to inhibit Mac1 of SARS-CoV-2, measurement of the affinity of active compounds and characterization of their binding mode by cocrystallization, uncovering critical molecular determinants of protein-ligand interaction. Key findings of the resulting structure-activity relationship (SAR) include that inhibitory potency is improved by either replacing the distal ribose of ADP-ribose by a small alkyl group or the adenine N7 by carbon. Based on insights from the SAR, we show β-methyl-GS-441524-diphosphate as nanomolar inhibitor that exhibits >1000-fold selectivity over human MacroD1 and MacroD2. Addition of C

Indexed as

Antiviral AgentsBetacoronavirusSARS-CoV-2AdenosineAdenosine Diphosphate RiboseAnimalsDrug DesignHumansProtein DomainsStructure-Activity RelationshipAdenosineAdenosine Diphosphate RiboseAntiviral AgentsGS-441524

Identifiers

PMID42509248
PMCPMC13408504

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.