ArticleThe Journal of pharmacology and experimental therapeutics2026
α-Synuclein regulates monoamine transporter capacity and amphetamine-induced efflux via modulation of transporter expression.
Article in The Journal of pharmacology and experimental therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
α-Synuclein (α-syn) is a presynaptic protein implicated in Parkinson disease and related synucleinopathies, but its physiological function remains incompletely understood. Monoamine transporters, including the dopamine transporter (DAT) and serotonin transporter (SERT), are key determinants of neurotransmitter clearance and primary targets of psychostimulant drugs. Although α-syn has been reported to interact with these transporters, its impact on transporter function remains unresolved. In the present study, we systematically manipulated α-syn expression in cellular models to determine its effects on DAT and SERT function. Overexpression of α-syn increased substrate uptake at both transporters, reflected by a selective increase in maximal transport velocity (V
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