ArticleClinical & experimental ophthalmology
Are Ocular Markers of Sun Exposure Associated With Skin Cancer? A Cross-Sectional Analysis of the Busselton Healthy Ageing Study.
Article in Clinical & experimental ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundHigher past sun or ultraviolet radiation exposure increases the risk of skin cancer and three common ocular findings: pterygium, conjunctival ultraviolet autofluorescence (CUVAF) and myopia. We investigated whether ocular markers of past sun exposure are associated with a history of skin cancer.
methodsA cross-sectional study of participants who attended the Phase 2 examination of the Busselton Healthy Ageing Study in Western Australia (2016-2022). Myopia was determined from autorefraction and pterygium and CUVAF from photographs of the anterior eye. Past diagnosis of a skin cancer was obtained from linked hospitalisation and cancer registry data (melanoma) or combining linked and self-reported data (keratinocyte cancer). Multivariable logistic regression with multiple imputation was used for analysis.
resultsOf 3888 participants who attended, 3829 (98.5%) had skin cancer history data (mean [standard deviation] age 64.2 [5.4] years). A history of keratinocyte cancer was present in 795 (20.8%) participants and cutaneous melanoma in 59 (1.5%) participants. After adjustments, keratinocyte skin cancer was associated with a current pterygium (odds ratio [OR] = 1.33, 95% confidence interval [CI]: 1.05, 1.69) and a previous self-reported pterygium excision (OR = 1.85, 95% CI: 1.21, 2.82). Neither CUVAF or myopia was associated with keratinocyte cancer or melanoma diagnoses.
conclusionsHaving a current pterygium or previous pterygium excision is associated with a diagnosis of keratinocyte skin cancer. While causality cannot be determined, the association may reflect shared risk factors such as chronic ultraviolet radiation exposure, and people with a pterygium should be advised that they are at higher risk of skin cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.