ReviewJournal of oral rehabilitation2026
The Interaction Between the Central Nervous System and Dental Tissues: Hypothetical Dental Interoception Inferred From Skeletal Interoception.
Review in Journal of oral rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe circuit of interoception, through which the nervous system monitors internal physiological states and maintains tissue homeostasis, has been well characterized in bone. However, whether a comparable interoceptive mechanism exists in the other mineralized tissue-teeth-remains unknown.
objectivesThis review uses skeletal interoception as a comparative framework to examine whether analogous sensory-regulatory mechanisms may operate in dental tissues. We summarize the neuroanatomical basis of dental innervation, the peripheral cellular mechanisms by which the pulp-dentine complex and periodontal ligament-alveolar bone complex sense and transduce local tissue states, and the reciprocal neural and effector responses that may contribute to dental homeostasis. Based on current evidence, we propose 'dental interoception' as a hypothetical conceptual framework for understanding neural-cellular regulation in teeth and their supporting tissues.
methodThe literature search was conducted in the PubMed and Web of Science databases, with a focus on how dental cells sense local tissue-state changes and communicate with the nervous system, as well as the direct regulation on odontogenesis-related cells by the nervous system.
resultsCurrent evidence suggests two potential modules of dental interoception: a pulp-dentine module that monitors intradental tissue states and supports pulp repair and reparative dentinogenesis, and a periodontal ligament-alveolar bone module that senses tooth load and regulates occlusal adaptation and alveolar bone remodelling. These modules involve pulpal cell-trigeminal nerve communication, reciprocal neural regulation of pulpal vascular, immune, stem-cell and reparative responses, and periodontal mechanoreceptor-guided remodelling. However, whether they form a complete peripheral-central-peripheral feedback loop remains unresolved.
conclusionThe bidirectional regulation between the nervous system and dental tissues is fundamental for maintaining dental homeostasis. Mapping the full circuitry underlying this interaction will be essential to establish dental interoception as a coherent physiological concept.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.