Evidence map›Paper›PMID 42508489›Full record

ArticleMayo Clinic proceedings2026

A 5-Year Population-Based Study of Polymicrobial Enterococcal Bloodstream Infection in Southeast Minnesota.

David R Bayless, Larry M Baddour, Brian D Lahr, Daniel C DeSimone

Abstract read
In one paragraph

Article in Mayo Clinic proceedings, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David R BaylessDepartment of Internal Medicine, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA. Electronic address: bayless.david@mayo.edu.
Larry M BaddourDivision of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA.
Brian D LahrDepartment of Quantitative Health Sciences, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA.
Daniel C DeSimoneDivision of Public Health, Infectious Diseases, and Occupational Medicine, Department of Medicine, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA; Department of Cardiovascular Medicine, Mayo Clinic College of Medicine & Science, Rochester, Minnesota, USA.

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS UL1 Supplement - Dr. Timothy Curry)UL1TR002377 · NCATS · MAYO CLINIC ROCHESTER · PI VESNA D GAROVIC · 2017 to 2026
$78.4M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NCATS NIH HHS UL1 TR002377NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738
6 · The paper itself

Abstract

objectiveTo study the incidence, epidemiology and clinical outcome of polymicrobial enterococcal bloodstream (PE-BSI) infection in a geographically defined population of adults in the United States. PATIENTS AND

methodsAll adult (age ≥18 years) residents within 8 counties in southeast Minnesota who developed a first-ever episode of PE-BSI from January 1, 2018, through December 31, 2022, were identified using the Expanded Rochester Epidemiology Project (E-REP) medical records linkage system. Incidence rates were based on the number of cases divided by the person-years in the population.

resultsDuring the 5-year study period, 66 incident PE-BSI cases were observed (median age 71.3 years; 72.7% male), corresponding to an age- and sex-adjusted incidence rate of 4.1 cases per 100,000 person-years. Multivariable analysis showed that older age and male sex were associated with increased PE-BSI incidence (both P<.001). The most common source of bloodstream infection was non-urinary intra-abdominal (40.9%). Enterococcus faecalis was the most common bloodstream isolate (69.7%). Primary concomitant bloodstream organisms were Escherichia coli (18.2%), Staphylococcus aureus (15.2%), and coagulase-negative Staphylococcus (15.2%). Despite low rates of definite infective endocarditis (3.2%) and BSI relapse (3.0%), mortality rates following PE-BSI were relatively high (31.8% at 12 weeks, 47.3% at 1 year).

conclusionIn this population-based study of 66 incident PE-BSI cases, increased incidence was associated with older age and male sex. A non-urinary intra-abdominal source was most often detected and cumulative mortality rates were high.

Indexed as

enterococciExpanded Rochester Epidemiology Projectmortalitypolymicrobial bloodstream infectionpopulation-based study

Identifiers

PMID42508489
PMCPMC13638214

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