Evidence map›Paper›PMID 42508402›Full record

ArticleStructure (London, England : 1993)2026

Matrix polyamines regulate bidirectional calcium flux through MCU.

Qinzhe Wang, Enrique Balderas, Alejandro Jara Ramos, Ashley Nwafor, Jack S McManus, Neeraj K Rai, Yasmin B Masini, David R Eberhardt, Emma C Rekate, Anthony M Balynas and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qinzhe WangDepartment of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Enrique BalderasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Alejandro Jara RamosNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Ashley NwaforDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Jack S McManusNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Neeraj K RaiNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Yasmin B MasiniNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
David R EberhardtNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Emma C RekateNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Anthony M BalynasNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Xue YinNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA.
Tracy Murray StewartDepartment of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA.
Erhu CaoDepartment of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Anna Stary-WeinzingerDivision of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Vienna, Austria.
Dipayan ChaudhuriNora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City, UT, USA; Departments of Internal Medicine, Biochemistry, Biomedical Engineering, and Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT, USA. Electronic address: dipayan.chaudhuri@hsc.utah.edu.

Funding

Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
The Stanford-SLAC CryoEM CenterR24GM154186 · NIGMS · STANFORD UNIVERSITY · PI Wah Chiu, BRITT HEDMAN · 2024 to 2026
$19.3M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Metabolic Impact and Mechanism of Enhanced Mitochondrial Calcium Uptake in Mitochondrial CardiomyopathiesR01HL141353 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2018 to 2026
$4.3M
Regulation of the mitochondrial calcium uniporterR01HL165797 · NHLBI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2022 to 2026
$2.5M
Mechanisms of mitochondria-driven hepatocyte injuryR01DK141142 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Dipayan Chaudhuri · 2025 to 2026
$1.5M
NHLBI NIH HHS R01 HL141353NHLBI NIH HHS R01 HL165797NIDDK NIH HHS R01 DK141142NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R24 GM154186NIGMS NIH HHS U24 GM129539NIGMS NIH HHS U24 GM129547
6 · The paper itself

Abstract

Polyamines, well-known regulators of the mitochondrial calcium (Ca

Indexed as

CalciumCalcium ChannelsPolyaminesAnimalsCryoelectron MicroscopyHumansMiceMitochondriaMolecular Dynamics SimulationProtein BindingCalciumCalcium Channelsmitochondrial calcium uniporterPolyaminescalcium channelsdisinhibitioninward rectificationMCUmitochondrial calcium uptakepolyamineputrescinespermidinespermine

Identifiers

PMID42508402
PMCPMC13508178

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.