Evidence map›Paper›PMID 42508324›Full record

ArticlePoultry science2026

Research note: Dietary resveratrol alleviates necrotic enteritis in broilers associated with in vitro inhibition of Clostridium perfringens and enhancement of host intestinal barrier function.

Ziqiang Chen, Yiming Li, Xiaoyang Ma, Jian Meng, Nihar Ali, Zhe Wang, Yanchao Guo, Yuxin Li, Hongbin Si

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziqiang ChenCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Yiming LiCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Xiaoyang MaCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Jian MengCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Nihar AliCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Zhe WangCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Yanchao GuoCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Yuxin LiCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China.
Hongbin SiCollege of Animal Science and Technology, Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, Guangxi grass station, Guangxi Universities Engineering Research Center of Forage Grass and Processing Utilization, Guangxi University, Nanning, 530004, Guangxi, China. Electronic address: 342162690@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Necrotic enteritis (NE), primarily caused by Clostridium perfringens (CP), represents a significant threat to the poultry industry. Resveratrol (RES) possesses antimicrobial properties, yet its effects against CP and protective role in NE-challenged broilers remain incompletely understood. In this study, the in vitro antibacterial activity of RES against CP was evaluated, and its regulatory effects on bacterial gene expression were analyzed using prokaryotic RNA-seq. An NE infection model was established to investigate the effects of post-challenge dietary RES (125, 250, or 500 mg/kg) on growth performance, intestinal lesions, barrier function, and inflammatory responses. Resveratrol exhibited potent antibacterial activity against CP with a minimum inhibitory concentration of 0.16 mg/mL and dose-dependently inhibited bacterial sliding motility and biofilm formation. Transcriptome analysis revealed downregulation of peptidoglycan biosynthesis and energy metabolism pathways. In NE-challenged broilers, post-challenge dietary RES (250 mg/kg) improved average daily gain, reduced feed conversion ratio, attenuated intestinal lesions, decreased serum FITC-dextran concentrations, upregulated tight junction proteins (Occludin, ZO-1) and mucin (MUC2), and suppressed pro-inflammatory cytokines (IL-1β, IL-6). These findings demonstrate that RES shows in vitro antibacterial activity against CP and is associated with improved intestinal barrier function and reduced inflammation in NE-challenged broilers, supporting its potential as a functional feed additive.

Indexed as

Clostridium perfringensIntestinal barrierNecrotic enteritisResveratrolTranscriptome

Identifiers

PMID42508324
PMCPMC13430178

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.