Evidence map›Paper›PMID 42507923›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

PLCβs are recruited to the plasma membrane in macrophages by both Gβγ and Gα

Maria E Falzone, Priyam Banerjee, Roderick MacKinnon

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Maria E FalzoneLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-6738-7017
Priyam BanerjeeBio-Imaging Resource Center, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-9398-9345
Roderick MacKinnonLaboratory of Molecular Neurobiology and Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0001-7605-4679

Funding

Activation of phospholipase C beta enzymes by G beta-gamma and corresponding regulation of downstream ion channelsF32GM142137 · NIGMS · ROCKEFELLER UNIVERSITY · PI FALZONE, MARIA ELIZABETH · 2021 to 2023
$205k
HHMI (HHMI) N/AHHS | NIH | National Institute of General Medical Sciences (NIGMS) F32GM142137NIGMS NIH HHS F32 GM142137
6 · The paper itself

Abstract

PLCβ enzymes cleave PIP2 from the plasma membrane, producing IP3 and DAG, which regulate intracellular Ca

Indexed as

Cell MembraneGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsMacrophagesPhospholipase C betaAnimalsCalciumMiceReceptors, G-Protein-CoupledSignal TransductionCalciumG-protein Beta gammaGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPhospholipase C betaReceptors, G-Protein-CoupledGPCR signalingGβγmacrophagesPIP2PLCβ3

Identifiers

PMID42507923
PMCPMC13438394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.