ArticleChemistry & biodiversity2026
Effects of Amaranthus spinosus Extract and Its Polyphenol Rich Fraction in Adenine-Induced Chronic Kidney Disease in Experimental Animals.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) is a progressive condition characterized by a decline in kidney function. Amaranthus spinosus is a medicinal plant reported for antioxidant, anti-inflammatory, and nephroprotective properties. The study evaluates the effectiveness of Amaranthus spinosus hydroalcoholic extract (250 mg/kg & 500 mg/kg) and its polyphenol rich fraction (50 mg/kg & 100 mg/kg) in an adenine-induced CKD in rats. CKD was induced in Sprague Dawley rats by oral administration of adenine (0.3% w/w) for 28 days, followed by a 28 days treatment with the extract and fraction. At the end of the study, biochemical parameters, inflammatory markers, glomerular filtration rate, TGF-β1, and Smad3 expressions were studied. Significant increase (p < 0.001) in BUN, creatinine, protein excretion rate, albumin excretion rate, and inflammatory cytokines was reported in only adenine-fed animals when compared with animals in the normal control group. Treatment with the extract and its fraction significantly increased GFR (p < 0.05 and p < 0.001, respectively). Treatment significantly affected biochemical parameters and inflammatory markers. Histopathological study indicated decreased kidney tissue damage. The higher dose of Amaranthus spinosus extract (500 mg/kg) exhibited decreased expression of TGF-β1 and Smad3 (p < 0.001 and p < 0.05, respectively). The results of the study indicate that Amaranthus spinosus has significant effects in CKD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.