Evidence map›Paper›PMID 42507664›Full record

ArticlePLOS digital health2026

A 60-second interpretable voice model for early dementia screening.

Kevin Mekulu, Faisal Aqlan, Hui Yang

Abstract read
In one paragraph

Article in PLOS digital health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kevin MekuluHarold and Inge Marcus Department of Industrial and Manufacturing Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America.ORCID https://orcid.org/0009-0004-8584-6693
Faisal AqlanDepartment of Industrial Engineering, University of Louisville, Louisville, Kentucky, United States of America.
Hui YangHarold and Inge Marcus Department of Industrial and Manufacturing Engineering, Pennsylvania State University, University Park, Pennsylvania, United States of America.

Funding

TREATMENT OF DEPRESSION IN ALZHEIMER'S DISEASEP50AG005133 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAMBOH, M. ILYAS · 1985 to 2019
$43.0M
NIA NIH HHS P50 AG005133
6 · The paper itself

Abstract

Early detection of cognitive impairment in assisted living is hindered by time-intensive tools like the Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA). We present a 60-second voice-based screening model that analyzes picture descriptions to estimate dementia risk. While recent deep learning approaches have shown promise on similar tasks, their lack of interpretability, large data requirements, and computational complexity limit clinical adoption. Using transcripts from the DementiaBank corpus, our model integrates traditional linguistic features (pause rate, pronoun use, syntactic complexity) with latent semantic dimensions extracted from language model embeddings. These semantic axes, interpretable constructs like "Drift & Hesitation" or "Over-detailed Narration", consistently emerged as top predictors and may represent novel linguistic biomarkers of early decline. The final ElasticNet classifier is sparse, interpretable, and outperforms known non-deep learning baselines (AUC = 0.858), exceeding MMSE. Its simplicity enables deployment in mobile apps or in-room monitors, offering scalable, low-burden screening for early dementia. This work supports a shift toward linguistically grounded, tech-enabled cognitive care in aging populations.

Identifiers

PMID42507664
PMCPMC13405093

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.