Evidence map›Paper›PMID 42507549›Full record

ArticleSTAR protocols2026

Protocol to study the antitumor and metabolic effects of intermittent fasting plus cisplatin and metformin in ovarian cancer PDX models.

Ludovica Perotti, Elena Capellini, Federica Guffanti, Anna Maria Ronchi, Daniela Corna, Domenico Cerullo, Cristina Matteo, Laura Sala, Eugenio Scanziani, Federica Maggi and 5 more

Abstract read
In one paragraph

Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ludovica PerottiLaboratory of Preclinical Gynecological Oncology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Elena CapelliniLaboratory of Preclinical Gynecological Oncology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Federica GuffantiLaboratory of Preclinical Gynecological Oncology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Anna Maria RonchiLaboratory of Clinical and Experimental Toxicology - Trace Elements Sector-Poison Control Center of Pavia - National Center for Toxicological Information- Scientific Clinical Institutes Maugeri SpA - SB, Via Salvatore Maugeri, 10, 27100 Pavia, Italy.
Daniela CornaUnit of Experimental Models of Kidney Disease, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Via Stezzano, 87, 24126 Bergamo, Italy.
Domenico CerulloUnit of Experimental Models of Kidney Disease, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Via Stezzano, 87, 24126 Bergamo, Italy.
Cristina MatteoLaboratory of Antitumor Pharmacology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Laura SalaVeterinary Medicine Department, University of Milan, Via Dell'Università 6, Lodi 26900, Italy, Mouse & Animal Pathology Lab (MAPLab), Fondazione UniMi, Viale Ortles, 22/4, Milan 20139, Italy.
Eugenio ScanzianiVeterinary Medicine Department, University of Milan, Via Dell'Università 6, Lodi 26900, Italy, Mouse & Animal Pathology Lab (MAPLab), Fondazione UniMi, Viale Ortles, 22/4, Milan 20139, Italy.
Federica MaggiLaboratory of Metabolites and Protein in Translational Research, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Melissa TiddiaLaboratory of Metabolites and Protein in Translational Research, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Flavia FunariLaboratory of Metabolites and Protein in Translational Research, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Giovanna DamiaLaboratory of Preclinical Gynecological Oncology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy.
Laura BrunelliLaboratory of Metabolites and Protein in Translational Research, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy. Electronic address: laura.brunelli@marionegri.it.
Francesca RicciLaboratory of Preclinical Gynecological Oncology, Department of Experimental Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via M. Negri 2, 20156 Milan, Italy. Electronic address: francesca.ricci@marionegri.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different dietary regimens are being explored as safe, low-cost approaches to enhance cancer therapy. This protocol describes the evaluation of antitumor and metabolic effects of intermittent fasting (IF) combined with cisplatin and metformin in an ovarian cancer patient-derived xenograft (PDX) model. Procedures include IF cycles, drug administration, antitumor activity assessment, drug quantification in plasma and tumors, toxicity evaluation, and immunohistochemical analyses. For complete information on the generation and use of this protocol, please refer to Capellini et al.

Indexed as

CancerMetabolismModel Organisms

Identifiers

PMID42507549
PMCPMC13446299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.