ArticleCell biochemistry and biophysics2026
Mitigation of D-Galactose-Induced Aging in Mice by Cymbopogon citratus and Its Major Bioactive Compound.
Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The biological process of aging is a progressive decline in physical ability and is characterized by oxidative stress and inflammation across multiple organs. Plant phytochemicals have emerged as promising candidate for exhibiting strong antioxidant and anti-inflammatory properties. Cymbopogon citratus (Lemongrass) exhibits strong antioxidant and anti-inflammatory properties that might counteract the key mechanisms involved in aging. The current study investigates the antiaging potential of Cymbopogon citratus extract (CCE), Cymbopogon citratus-mediated silver nanoparticles (CCE-AgNPs) and Citral (Cit) in a D-galactose-induced aging mice model. In vivo evaluation was performed after inducing aging in mice by administering a dose of 250 mg per kg for 60 days continuously via intraperitoneal route followed by treatment with the respective test formulations. A dose of 250 mg per kg of CCE, 200 mg per kg dose of CCE-AgNPs, 200 mg per kg of Cit and 150 mg per kg of metformin was used a treatment. Different biochemical parameters revealed that out of all the treatments, CCE-AgNPs significantly resulting in peak values of CAT (148.6 ± 49.8 U/ml), SOD (157.2 ± 12.6 U/ml), GPx (43.0 ± 1.8 U/ml), GRx (23.0 ± 4.1 U/ml). Also, lower MDA, FSH and cortisol levels indicated strong antiaging potential of Cymbopogon citratus mediated AgNPs. Moreover, the histological findings of liver, brain and kidney of D-galactose group showed oxidative stress induced changes while CCE AgNPs improved the histopathological changes induced by D-galactose, making a potential future in antiaging research field.
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