ArticlePlanta2026
The transcriptional coactivator ZaGIF2 from Zanthoxylum armatum enhances growth and drought tolerance in plants by synergistically activating GRF activity.
Article in Planta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MAIN
conclusionIn this study, the transcriptional coactivator ZaGIF2, isolated from Zanthoxylum armatum, enhances plant growth and drought tolerance by synergistically activating GRF transcription factors in plants. Growth-regulating factor-interacting factors (GIFs) are conserved transcriptional coactivators in plants that regulate growth and development by forming complexes with growth-regulating factors (GRFs). However, their functions in woody plants, especially in non-model species, and their specific roles in coordinating growth and stress resistance remain unclear. In this study, a GIF gene, ZaGIF2, was cloned from the economically important species Zanthoxylum armatum var. dintanensis. ZaGIF2 exhibited the highest expression in apical buds with active meristems, and its transcription was significantly induced by naphthaleneacetic acid (NAA), abscisic acid (ABA), and drought stress. The encoded protein was localized to the nucleus. Overexpression of ZaGIF2 in Nicotiana benthamiana and Arabidopsis thaliana simultaneously promoted leaf enlargement and enhanced drought tolerance. Transgenic plants demonstrated improved water retention capacity, reduced oxidative damage, and enhanced osmotic adjustment. Overexpression of ZaGIF2 upregulated the expression of multiple growth-related genes (AtPIF4, AtLBD18, AtTCP14) and drought-responsive genes (DREB2A, P5CS1, RD26, RD29). Mechanistically, the ZaGIF2 protein directly interacted with AtGRF1 and AtGRF3 and significantly enhanced their transcriptional activation activity. Collectively, our findings reveal a novel mechanism in woody plants whereby a GIF protein improves plant growth and drought adaptation by interacting with and enhancing the activity of GRF transcription factors. This study provides important genetic resources and a theoretical foundation for the synergistic improvement of growth and stress resistance traits in forest trees using the conserved GIF-GRF module.
Indexed as
Identifiers
42507185What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.