Evidence map›Paper›PMID 42507090›Full record

ArticleBulletin of experimental biology and medicine2026

CLOCK rs1801260 and MTNR1B rs10830963 Polymorphisms Modulate the Association between Cholesterol Levels and Circadian Rhythms in Arctic Residents.

D G Gubin, S N Kolomeychuk, I M Petrov, A A Markov, Yu A Petrova, K A Voronin, M S Mezhakova, Y V Boldyreva, A U Shigabaeva

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

D G GubinTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia. dgubin@mail.ru.
S N KolomeychukTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
I M PetrovTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
A A MarkovTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
Yu A PetrovaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
K A VoroninTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
M S MezhakovaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
Y V BoldyrevaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.
A U ShigabaevaTyumen State Medical University, Ministry of Health of the Russian Federation, Tyumen, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extreme photoperiods in the Arctic (polar day, polar night, and spring equinox) can disrupt circadian rhythms and impact metabolism and health. The study was aimed to assess the association between the phase angle of physical activity relative to received blue light (ψPA-BL) and the lipid profile. The study included 64 participants who underwent seasonal 7-day actigraphy with an RGB sensor, as well as genotyping for CLOCK rs1801260 and MTNR1B rs10830963 polymorphisms. Multiple regression analysis adjusting for photoperiod, age, and sex showed that ψPA-BL is a predictor of total cholesterol and LDL cholesterol levels only in individuals with the TT/CC genotypes (p < 0.0001). This TT/CC combination exhibited the strongest association with total cholesterol (r = -0.684, explained variance = 47%) and LDL cholesterol (r = -0.623, explained variance = 39%).

Indexed as

CholesterolCircadian RhythmCLOCK ProteinsReceptor, Melatonin, MT2AdultArctic RegionsBlue LightCholesterol, LDLFemaleGenotypeHumansMalePhotoperiodPolymorphism, Single NucleotideCholesterolCholesterol, LDLCLOCK protein, humanCLOCK ProteinsMTNR1B protein, humanReceptor, Melatonin, MT2ArcticcholesterolCLOCK genelightMTNR1B gene

Identifiers

PMID42507090

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.