Evidence map›Paper›PMID 42507088›Full record

ArticleBulletin of experimental biology and medicine2026

Comparative Evaluation of the Effects of Agar and Biofilm Cultures of Francisella tularensis on the Immunological Reactivity of Experimental Animals.

V I Dubrovina, T P Starovoitova, A B Pyatidesyatnikova, T A Ivanova, A V Mazepa, K V Naumova, A K Syngeeva, S V Balakhonov

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

V I DubrovinaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru.
T P StarovoitovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
A B PyatidesyatnikovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
T A IvanovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
A V MazepaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
K V NaumovaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
A K SyngeevaIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.
S V BalakhonovIrkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied immunogenic properties of biofilm and agar cultures of Francisella tularensis strains. Analysis of the interaction of F. tularensis biofilm cultures with macrophages from experimental animals showed that the bacteria adapt to adverse conditions by forming biofilms, thereby increasing their virulence and subsequently suppressing the functional activity of immune cells. Biofilm formation in 7-day-old cultures of F. tularensis strains was associated with an increase in the virulent potential, which led to a decrease in the mean survival time and the overall survival rate of the experimental animals.

Indexed as

AgarBiofilmsFrancisella tularensisTularemiaAnimalsCulture MediaMacrophagesMicePhagocytosisVirulenceAgarCulture MediabiofilmFrancisella tularensisimmunogenic propertiesphagocytic activity

Identifiers

PMID42507088

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.