Evidence map›Paper›PMID 42507075›Full record

ArticleNeuroscience bulletin2026

Astrocytic Prostaglandin Transporter SLCO2A1-Ca

Taozhi Wang, Manping Yang, Haiyun Guo, Hongyu Ma, Zhenzhen Li, Junjun Kang, Yaomin Guo, Shengxi Wu, Yazhou Wang, Wugang Hou

Abstract read
PubMed Publisher
In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taozhi WangDepartment of Anesthesiology and Perioperative Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Manping YangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Haiyun GuoDepartment of Anesthesiology and Perioperative Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Hongyu MaDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Zhenzhen LiDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Junjun KangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yaomin GuoDepartment of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Shengxi WuDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China.
Yazhou WangDepartment of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi'an, 710032, China. yzwang@fmmu.edu.cn.
Wugang HouDepartment of Anesthesiology and Perioperative Medicine, Key Laboratory of Anesthesiology, Ministry of Education of China, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China. gangwuhou@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prostaglandin E2 (PGE2) plays diverse roles in secondary injury after ischemic stroke. Solute carrier organic anion transporter family member 2A1 (SLCO2A1) is a key transporter of PGE2; however, its role in the pathophysiology of cerebral ischemia remains largely unknown. Here, we report that ischemia induces transient upregulation of SLCO2A1 in reactive astrocytes. Local knockdown of Slco2a1 in astrocytes disrupted astrocyte-endothelial cell contact, resulting in extravascular IgG accumulation and exacerbated functional deficits. In contrast, overexpression of SLCO2A1 in astrocytes significantly reduced blood-brain barrier (BBB) disruption and promoted locomotor recovery. Mechanistically, intracellular Ca

Indexed as

Blood-brain barrierCa2+Reactive astrocytesSLCO2A1

Identifiers

PMID42507075

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.