ArticleBioresources and bioprocessing2026
Biocircular economy-driven bacterial cellulose with large pore size: statistical optimization using Glutamicibacter soli bread waste hydrolysate.
Article in Bioresources and bioprocessing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bacterial cellulose (BC) is a versatile biopolymer of considerable biotechnological interest, with wide-ranging applications in biomedical, industrial, and engineering fields attributable to its exceptional structural and physicochemical properties. Despite its promise, the high cost of conventional production media and the challenge of tailoring BC structural characteristics remain critical bottlenecks limiting sustainable large-scale manufacturing. In the present study, a novel fermentation medium based on Glutamicibacter soli bread waste hydrolysate (BWH) was developed and statistically optimized for high-yield BC production by Komagataeibacter sp. strain HIJ12 EMCCN-4085, integrating circular bioeconomy principles through food waste valorization. One-variable-at-a-time (OVAT) screening identified glycerol and ethanol supplementation, incubation at 28 °C, pH 5.5, a 2-day-old inoculum, and an aeration ratio of zbroth: flask volume) as the key determinants governing BC biosynthesis. Subsequent Box-Behnken design-based Response Surface Methodology, supported by canonical and ridge analyses, refined glycerol concentration, inoculum size, and incubation time, yielding an exceptional BC dry weight of 39 g L
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