Evidence map›Paper›PMID 42507021›Full record

ArticleSurgery today2026

A novel diagnostic role of 99mTc-GSA scintigraphy in distinguishing hepatocellular carcinoma from hepatic angiomyolipoma.

Tomohiko Taniai, Kenei Furukawa, Kazutaka Gomisawa, Ken Watanabe, Kazuyoshi Ohki, Koichiro Haruki, Mitsuru Yanagaki, Yuto Yamahata, Masayuki Shimoda, Toru Ikegami

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tomohiko TaniaiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Kenei FurukawaDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan. k-furukawa@jikei.ac.jp.
Kazutaka GomisawaDepartment of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Ken WatanabeDepartment of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Kazuyoshi OhkiDepartment of Radiology, The Jikei University School of Medicine, Tokyo, Japan.
Koichiro HarukiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Mitsuru YanagakiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yuto YamahataDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.
Masayuki ShimodaDepartment of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Toru IkegamiDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHepatic angiomyolipoma (HAML) is a rare benign liver tumor that is difficult to differentiate from hepatocellular carcinoma (HCC) preoperatively. This study aimed to evaluate the diagnostic value of Technetium-99 m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin (99mTc-GSA) scintigraphy for HAML.

methodsSix patients with HAML were enrolled, and 139 patients with hepatocellular carcinoma were analyzed as a control group. Imaging findings from computed tomography, magnetic resonance imaging, and 99mTc-GSA scintigraphy were investigated, and the radioactivity of 99mTc-GSA scintigraphy was measured in patients with HAML and HCC.

resultsIn 5 cases, early enhancement was observed in five cases, and three cases showed washout in the delayed phase. Hepatocyte phase defects were detected in all cases, and early venous return was observed in two cases. All cases showed a defect in radioactivity on 99mTc-GSA scintigraphy, and the immunohistochemistry of asialoglycoprotein receptor (ASGPR) was negative in HAML compared to normal liver tissue in all cases. The tumor-to-liver signal ratio was significantly higher in hepatocellular carcinoma than in hepatic angiomyolipoma (p < 0.01).

conclusion99mTc-GSA scintigraphy may help distinguish hepatic angiomyolipoma from hepatocellular carcinoma.

Indexed as

99mTc-GSA scintigraphyHepatic angiomyolipomaHepatocellular carcinoma

Identifiers

PMID42507021

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