Impact of Time, Temperature, and Conformational Changes on the Characterization of Cardiotonic Steroid-Na

Pedro Azalim-Neto, Leandro Barbosa, Cristoforo Scavone, Luis Eduardo M Quintas

Abstract readReview

In one paragraph

Review in The Journal of membrane biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pedro Azalim-NetoLaboratório de Neurofarmacologia Molecular, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil. pedroazalim94@gmail.com.ORCID http://orcid.org/0000-0003-3272-4321

Leandro BarbosaLaboratório de Bioquímica Celular, Universidade Federal de São João del- Rei (UFSJ) Campus Centro-Oeste Dona Lindu, Divinópolis, MG, Brazil.ORCID http://orcid.org/0000-0002-4631-0130

Cristoforo ScavoneLaboratório de Neurofarmacologia Molecular, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-1206-0882

Luis Eduardo M QuintasLaboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-0767-1240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiotonic steroids (CTS) have gained prominence due to various mechanisms of action proposed or demonstrated to explain their effects, including their known classical and non-classical signaling pathways mediated by Na

Indexed as

Cardiac GlycosidesSodium-Potassium-Exchanging ATPaseAnimalsHumansKineticsProtein BindingProtein ConformationTemperatureThermodynamicsCardiac GlycosidesSodium-Potassium-Exchanging ATPaseDrug screeningHigh-throughput assaysP-type ATPase modulationResidence time.Structure–function relationshipThermodynamic profiling

Identifiers

PMID42506999

DOI10.1007/s00232-026-00385-4

PMCPMC13407939

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.