Evidence map›Paper›PMID 42506979›Full record

ArticleeLife2026

Reprogramming of host energy metabolism mediated by the TNF-iNOS-HIF-1α axis plays a key role in host resistance to

Kely Catarine Matteucci, Nathalia P S Leite, Patricia A Assis, Isabella Cristina Hirako, Franciele Pioto, Ogooluwa Ojelabi, Juliana E Toller-Kawahisa, Leonardo Gomes Vaz, Diego Luis Costa, João S da Silva and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Immune regulation of host energy metabolism and periodicity of malaria parasites.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kely Catarine MatteucciTranslational Medicine Platform Oswaldo Cruz Foundation, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-2474-1837
Nathalia P S LeiteTranslational Medicine Platform Oswaldo Cruz Foundation, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-0275-2949
Patricia A AssisDepartment of Pathology, University of Michigan Medical School, Ann Arbor, United States.
Isabella Cristina HirakoLaboratory of Immunopathology, Instituto René Rachou, Fundação Oswaldo Cruz - Minas, Belo Horizonte, Brazil.
Franciele PiotoTranslational Medicine Platform Oswaldo Cruz Foundation, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.
Ogooluwa OjelabiDepartment of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Chan Medical School, Worcester, United States.
Juliana E Toller-KawahisaDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.
Leonardo Gomes VazTechnology Center for Vaccines, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Diego Luis CostaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.
João S da SilvaTranslational Medicine Platform Oswaldo Cruz Foundation, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.
José C Alves-FilhoDepartment of Pharmacology, Ribeirão Preto Medical School, University of Sao Paulo, São Paulo, Brazil.
Ricardo T GazzinelliTechnology Center for Vaccines, Federal University of Minas Gerais, Belo Horizonte, Brazil.ORCID https://orcid.org/0000-0003-2427-7699

Funding

Innate Immune Activation in MalariaR01AI079293 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., GOLENBOCK, DOUGLAS T · 2009 to 2024
$10.9M
Monocyte-derived dendritic cells in malariaR01NS098747 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES, LUSTER, ANDREW D · 2016 to 2020
$2.1M
Host Ciracadian Clock and MalariaR21AI150546 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GAZZINELLI, RICARDO TOSTES · 2020 to 2021
$461k
Conselho Nacional de Desenvolvimento Científico e Tecnológico 465293/2014-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 465293/2014-0Fundação de Amparo à Pesquisa do Estado de Minas Gerais 465293/2014-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/23618-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/01043-9National Institute of Allergy and Infectious Diseases 1R21 AI150546-01National Institute of Allergy and Infectious Diseases R01AI079293National Institute of Allergy and Infectious Diseases R01NS098747NIAID NIH HHS R01 AI079293NIAID NIH HHS R21 AI150546NINDS NIH HHS R01 NS098747
6 · The paper itself

Abstract

TNF has a dual effect in

Indexed as

Disease ResistanceHypoxia-Inducible Factor 1, alpha SubunitMalariaMetabolic ReprogrammingNitric Oxide Synthase Type IITumor Necrosis Factor-alphaAnimalsEnergy MetabolismFemaleGlucoseGlucose Transporter Type 1GlycolysisLiverMiceMice, Inbred C57BLMice, KnockoutGlucoseGlucose Transporter Type 1Hif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNitric Oxide Synthase Type IINos2 protein, mouseReactive Nitrogen SpeciesSlc2a1 protein, mouseTumor Necrosis Factor-alphaimmunologyimmunometabolisminfectious diseaseinflammationmalariamicrobiologymousep. chabaudiTNF

Identifiers

PMID42506979
PMCPMC13405620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.