ArticleJournal of clinical microbiology2026
A comparative performance evaluation of the VIDAS cytomegalovirus (CMV) interferon-gamma release assay (IGRA) and T-SPOT CMV for measuring CMV-specific T-cell responses in allogeneic hematopoietic stem cell transplant recipients receiving letermovir prophylaxis.
Article in Journal of clinical microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- A multiparameter whole blood platform for assessment of anti-CMV immunity in allogeneic stem cell transplantation recipients.Frontiers in immunology · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
Assessment of cytomegalovirus (CMV) cell-mediated immunity (CMV-CMI) using standardized, commercially available interferon-gamma release assays (IGRAs) may improve the clinical management of CMV infection in allogeneic hematopoietic stem cell transplant recipients (allo-HCT). Studies comparing the performance of CMV IGRA assays have been conducted in this setting, revealing frequent discrepancies between assays. Here, we compared the performance of a newly released VIDAS CMV IGRA (bioMérieux) and the T-SPOT. CMV (Oxford Immunotec) was evaluated in a cohort of 85 allo-HCT recipients who received letermovir prophylaxis. A total of 107 whole blood samples were collected at either day +100 ( IMPORTANCE: This is the first study comparing a new interferon-gamma release assay (IGRA), the VIDAS cytomegalovirus (CMV), performed on whole blood and based on an enzyme-linked immunofluorescent assay detection technique, with a commercially available ELISpot assay (T-SPOT CMV) for measuring CMV-specific T-cell responses (CMV-CMI). Our cohort included allogeneic hematopoietic stem cell transplant recipients who underwent letermovir prophylaxis. In this clinical setting, tailoring the duration of LMV prophylaxis based on CMV-CMI at the time of drug discontinuation has emerged as a promising application of these assays. Our data revealed substantial qualitative and quantitative differences between the assays, which should be taken into consideration in future observational studies or clinical trials assessing the utility of IGRAs for individualizing LMV prophylaxis duration.
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