ArticleJournal of biochemical and molecular toxicology2026
β-Elemene Triggers Drp1-Dependent Mitochondrial Fission Through CDK1/Cyclin B1 Signaling in Cervical Cancer Cells.
Article in Journal of biochemical and molecular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- β-Elemene Triggers Drp1-Dependent Mitochondrial Fission Through CDK1/Cyclin B1 Signaling in Cervical Cancer Cells.Journal of biochemical and molecular toxicology · 2026Article
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Authors and funding
7 authors.
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Abstract
Mitochondrial dynamics, regulated by fission and fusion, are frequently altered in cancers, influencing cell survival and metabolism. The sesquiterpene β-elemene exhibits anti-tumor activity, but its effect on mitochondrial dynamics in cervical cancer is unknown. This study investigated whether β-elemene exerts its anti-tumor effects by disrupting mitochondrial homeostasis. We found that β-elemene treatment dose-dependently reduced viability and increased lactate dehydrogenase release in HT-3 and Caski cervical cancer cells. In HT-3 cells, β-elemene induced mitochondrial oxidative stress, impaired respiratory function, and triggered extensive mitochondrial fragmentation. Mechanistically, β-elemene promoted phosphorylation of dynamin-related protein 1 (Drp1) at Ser616 and its translocation to mitochondria. Furthermore, β-elemene enhanced the interaction between cyclin-dependent kinase 1 (CDK1) and cyclin B1. Genetic silencing of CDK1 abrogated β-elemene-induced Drp1 activation, mitochondrial fragmentation, and bioenergetic deficits. Collectively, these data identify a novel pathway through which β-elemene drives CDK1-dependent Drp1 activation, leading to excessive mitochondrial fission and dysfunction in cervical cancer cells.
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