ArticleJournal of functional biomaterials2026
Preclinical Evaluation of a Chitosan-Based Field Hemostatic Sponge in Arterial Bleeding Models with and Without Aspirin Administration.
Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BACKGROUND/
objectivesThis study evaluated the hemostatic efficacy of a chitosan-based field hemostatic sponge (FHS), the first hemostatic product of this type manufactured in Vietnam, across bleeding models of varying injury severity under both normal physiological conditions and after aspirin administration.
methodsAn in vivo experimental study was conducted using two models: (1) a rabbit ear incision model in New Zealand White rabbits and (2) a femoral artery puncture model in Wistar rats and New Zealand White rabbits. Animals were randomly allocated to six groups: medical gauze (control), FHS, Axiostat
resultsIn the rabbit ear incision model, FHS reduced time to hemostasis by 57.6% and blood loss by 69.9% compared with medical gauze (
conclusionsFHS demonstrated potent and consistent hemostatic efficacy across multiple injury severities and animal species; the hemostatic efficacy of FHS was maintained after aspirin administration, indicating that the material's efficacy is not entirely dependent on platelet function. These findings support its potential clinical application in hemorrhage control, including in patients with coagulation disorders or receiving antiplatelet therapy.
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