Evidence map›Paper›PMID 42506574›Full record

ArticleJournal of functional biomaterials2026

Hydrolytically Stable Organo-Chemical Surface Functionalization of Bioinert High-Performance Ceramics Enables Osseoconduction and Osseointegration In Vivo.

Rald V M Groven, Changlin Qi, Philipp Schräder, Deniz D Özman, Lisa Ernst, Zhen Che, Naeem Assasa, Markus Tingart, Frank Hildebrand, Sabine Neuss-Stein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rald V M GrovenDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Changlin QiExperimental Orthopedics and Trauma Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0009-0004-0741-1512
Philipp SchräderDepartment of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Deniz D ÖzmanDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Lisa ErnstInstitute for Laboratory Animal Science, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0000-0003-3808-4222
Zhen CheDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.ORCID 0000-0002-5649-9512
Naeem AssasaElectron Microscopy Facility, Institute of Pathology, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Markus TingartDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Frank HildebrandDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Sabine Neuss-SteinHelmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University Hospital, Pauwelsstraße 20, 52074 Aachen, Germany.
Horst FischerDepartment of Dental Materials and Biomaterials Research, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.
Hanno SchenkerDepartment of Orthopedic, Trauma and Reconstructive Surgery, RWTH Aachen University Hospital, Pauwelsstraße 30, 52074 Aachen, Germany.

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt 13GW0452A
6 · The paper itself

Abstract

Metal alloys in arthroplasty face limitations including aseptic loosening, material failure, and allergic reactions. High-performance oxide ceramics (HPOCs) represent an alternative but are bioinert, restricting osseointegration and osteoconduction. The aim of this study was to convert bioinert HPOC surfaces into bioactive osteogenic microenvironments through stable peptide-biofunctionalization with cyclic-arginylglycylaspartic acid (cRGD) or modified-hepatocyte growth factor (mod-HGF). In a rabbit femoral defect model, cylindrical ATZ implants were press-fitted into 4.5 × 8 mm defects and examined after 18 weeks. Three groups were compared: uncoated ATZ, cRGD-coated, and mod-HGF-coated implants (

Indexed as

Biological functionalizationcRGDimplantologymod-HGFosseointegration

Identifiers

PMID42506574
PMCPMC13413193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.