ArticleJournal of functional biomaterials2026
Remineralization of Artificial Caries-like Lesions in Permanent Enamel by MI Paste One: Comparative Physicochemical Outcomes and In Vitro Resistance to Secondary Demineralization.
Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPatients with White spot lesions (WSLs) are seeking minimally invasive remineralizing treatment. While fluoride is the gold standard of non-invasive caries therapy, its remineralizing impact is predominantly superficial. MI Paste One (MIP-1) combines casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with 1100 ppm fluoride. This in vitro study aimed to assess the effect of MIP-1 compared with other agents.
methodsEnamel slabs were demineralized to create a caries-like lesion and randomized into five groups (
resultsAll active agents improved microhardness after treatment. After secondary demineralization, G4 achieved the highest hardness, significantly superior to G3 (
conclusionsMIP-1 outperformed fluoride toothpaste in resisting secondary demineralization of permanent enamel WSLs. CPP-ACP made a measurable independent contribution to demineralization resistance in permanent enamel. These findings highlight the need for further clinical investigation of MIP-1.
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