ArticleJournal of functional biomaterials2026
Balancing Osseointegration and Infection Control: The Role of Titanium Surface Topography in Peri-Implant Biology.
Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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14 authors.
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Abstract
backgroundPeri-implant infections remain a major cause of dental implant failure, largely due to bacterial adhesion and biofilm formation on implant surfaces. This study aimed to investigate how surface topography influences bacterial colonisation and osteoblastic response.
methodsTitanium discs with machined (Ma), sandblasted, large-grit, and acid-etched (SLA), and nanostructured (Nano) surfaces were prepared, sterilised, and seeded with pre-differentiated dental follicle mesenchymal stem cells. Co-cultures with
resultsNano surfaces showed the highest osteoblastic adhesion and viability, while significantly reducing bacterial proliferation and biofilm formation compared with Ma and SLA surfaces. The sequence of colonisation influenced cell-bacteria dynamics, with early cell attachment limiting subsequent bacterial adhesion.
conclusionsNano titanium surfaces may offer a dual benefit by promoting osseointegration while limiting bacterial adhesion. These findings support their potential use as surface modifications to reduce peri-implant infection risk and improve long-term implant success.
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