Evidence map›Paper›PMID 42506306›Full record

SynthesisMedical sciences (Basel, Switzerland)2026

Pharmacological and Clinical Heterogeneity of Anti-Amyloid Monoclonal Antibodies in Early Alzheimer's Disease: A Systematic Review and Meta-Analysis of Randomized Trials.

Albert Vamanu, Alexandra Mastaleru, Thomas Gabriel Schreiner, Gabriela Popescu, Adina Maria Roceanu, Andrei Ionut Cucu, Alexandru Patrascu, Georgiana-Anca Vulpoi, Robert-Valentin Bilcu, Romica Sebastian Cozma and 5 more

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Medical sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Albert VamanuBasic and Clinical Neuroscience Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK.
Alexandra MastaleruGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-0008-9696
Thomas Gabriel SchreinerGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-4495-4004
Gabriela PopescuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0000-7004-6846
Adina Maria RoceanuNeurology Department, University Emergency Hospital Bucharest, 020021 Bucharest, Romania.ORCID 0000-0002-4860-3324
Andrei Ionut CucuEmerald Hospital Iasi, 700115 Iasi, Romania.ORCID 0000-0003-1441-1751
Alexandru PatrascuApollonia University, 700511 Iasi, Romania.
Georgiana-Anca VulpoiGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Robert-Valentin BilcuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Romica Sebastian CozmaGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-3768-6232
Raluca OlariuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0001-1221-5397
Cătălina Elena BistriceanuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Roxana CovaliGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0000-0002-7386-0859
Dan Iulian CuciureanuGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.
Alin CiubotaruGrigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania.ORCID 0009-0003-2079-2383

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBiomarkersHumansRandomized Controlled Trials as TopicAmyloid beta-PeptidesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBiomarkersaducanumabAlzheimer’s diseaseamyloid-related imaging abnormalities (ARIA)anti-amyloid therapyCDR-SBdisease-modifying therapydonanemabgantenerumablecanemabmeta-analysismonoclonal antibodiesrandomized controlled trials

Identifiers

PMID42506306
PMCPMC13413489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.