ReviewJournal of fungi (Basel, Switzerland)2026
The Mevalonate Pathway: Innovations, Applications, and Challenges in Biotechnology with Emphasis on Fungal Biology.
Aisel Valle Garay, Cíntia Marques Coelho, Napoleão Fonseca Valadares, Leonardo Ferreira da Silva, Letícia Sousa Cabral, Matheus de Castro Leitão, Luiza Cesca Piva, Janice Lisboa De Marco, Brenda Rabello de Camargo, Amanda Araújo Souza and 7 more
Abstract readReview
In one paragraphReview in Journal of fungi (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
17 authors.
Aisel Valle GarayLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.
Cíntia Marques CoelhoLaboratory of Synthetic Biology, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0002-8564-3587 Napoleão Fonseca ValadaresLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.
Leonardo Ferreira da SilvaLaboratory of Synthetic Biology, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.
Letícia Sousa CabralLaboratory of Synthetic Biology, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.
Matheus de Castro LeitãoLaboratory of Synthetic Biology, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0002-5293-9349 Luiza Cesca PivaMicrobial Genetics and Biotechnology Laboratory, EMBRAPA Agroenergy, Parque Estação Biológica (PqEB), Ave. W3 Norte (Final), s/n, Edifício da EMBRAPA Agroenergia, Brasília-DF 70770-901, Brazil.ORCID 0000-0002-2038-8749 Janice Lisboa De MarcoPharmacy Department, Faculty of Health, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0001-9252-698X Brenda Rabello de CamargoYeast Molecular Genetics Laboratory, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.
Amanda Araújo SouzaLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.
Izadora Cristina Moreira de OliveiraLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0003-2918-1696 Matheus Ferroni SchwartzLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0002-0215-3620 Túlio Marcos Godoy de AndradeMicrobial Genetics and Biotechnology Laboratory, EMBRAPA Agroenergy, Parque Estação Biológica (PqEB), Ave. W3 Norte (Final), s/n, Edifício da EMBRAPA Agroenergia, Brasília-DF 70770-901, Brazil.ORCID 0009-0001-3229-255X Talita Souza CarmoLaboratory of Biocatalyst and Bioprocess Engineering, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0003-0868-1720 João Ricardo Moreira de AlmeidaMicrobial Genetics and Biotechnology Laboratory, EMBRAPA Agroenergy, Parque Estação Biológica (PqEB), Ave. W3 Norte (Final), s/n, Edifício da EMBRAPA Agroenergia, Brasília-DF 70770-901, Brazil.ORCID 0000-0002-2902-5805 Fernando Araripe Gonçalves TorresYeast Molecular Genetics Laboratory, Center for Molecular Biotechnology (C-Biotech), University of Brasília Science and Technology Park (PCTec), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0002-3650-7271 Sonia Maria de FreitasLaboratory of Molecular Biophysics, Department of Cell Biology, Institute of Biological Sciences, University of Brasília (UnB), Asa Norte, Brasília-DF 70910-900, Brazil.ORCID 0000-0002-7562-4980 Funding
Foundation for Research Support of the Federal District Agrolearning process N.19300002587/2022-59Foundation for Research Support of the Federal District N.00193-00002414/2023-11Institutos Nacionais de Ciência e Tecnologia and FAPDF: project N.00193-00002141/2023-13National Council for Scientific and Technological Development CNPq-INCT process N.406375/2022-4National Council for Scientific and Technological Development Grant ICMO Processo N.408969/202-3, Chamada CPNq/MCTI n°44/2024National Council for Scientific and Technological Development Grant N.305819/2022-4National Council for Scientific and Technological Development Grant N.351758/2025-9National Council for Scientific and Technological Development process N.402772/2023-7
6 · The paper itselfAbstract
The mevalonate (MVA) pathway is a central metabolic route responsible for the biosynthesis of isoprenoids with broad biological and biotechnological relevance. Due to its importance, the MVA pathway has attracted increasing interest in studies of enzymatic regulation, structural biology, metabolic engineering, and synthetic biology, particularly in fungi. This review provides a comprehensive overview of the MVA pathway, addressing its distribution across different domains of life, evolutionary aspects, and metabolic organization, with emphasis in fungi. Special attention is given to the biochemical and structural characterization of MVA-pathway enzymes, including catalytic mechanisms, structural features, and regulatory processes. The methylerythritol phosphate pathway is also presented as an alternative route for isoprenoid precursor biosynthesis and discussed in terms of its taxonomic distribution and metabolic significance. Recent advances in synthetic biology, enzyme regulation, and pathway engineering are highlighted, emphasizing their contributions to metabolic engineering and synthetic biology. Special emphasis is given to fungi, in which the MVA pathway plays a central role in ergosterol biosynthesis, protein prenylation, and secondary metabolite production. Advances in the engineering of fungal cells, including
Indexed as
applications of isoprenoidfungiisoprenoidsmetabolic engineeringmevalonatemevalonate pathwayproduction of isoprenoidsyeast
Identifiers
PMID42506259
PMCPMC13412983
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390