Evidence map›Paper›PMID 42506224›Full record

ArticleJournal of fungi (Basel, Switzerland)2026

Effects of Carvacrol on Morphogenesis and Lipase-Associated Phenotypes in Clinical Isolates of

Iasmin Freitas Pimentel Pequeno, Larissa Alves da Silva, Luanna de Oliveira E Lima, Meryellem Bezerra Soares, Camila Mendes Soares, Raimundo Euzébio da Costa Neto, José Maria Barbosa Filho, Felipe Queiroga Sarmento Guerra, Guilherme Maranhão Chaves, Walicyranison Plínio da Silva Rocha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iasmin Freitas Pimentel PequenoClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.ORCID 0000-0002-2620-1869
Larissa Alves da SilvaClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.ORCID 0000-0001-5073-7033
Luanna de Oliveira E LimaClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.
Meryellem Bezerra SoaresClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.ORCID 0009-0007-1734-1177
Camila Mendes SoaresClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.
Raimundo Euzébio da Costa NetoClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.
José Maria Barbosa FilhoPharmaceutical Technology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, Paraíba, Brazil.ORCID 0000-0002-9567-4096
Felipe Queiroga Sarmento GuerraClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.ORCID 0000-0003-2057-4821
Guilherme Maranhão ChavesLaboratory of Medical Mycology, DMIC-Department of Mycology-BC, Federal University of Pernambuco, Recife 50670-901, Pernambuco, Brazil.
Walicyranison Plínio da Silva RochaClinical Mycology Laboratory, Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-900, Paraíba, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

methodsThirteen clinical isolates of

resultsCarvacrol reduced germ tube formation in most of the evaluated strains and decreased the overall morphology index, indicating attenuation of filamentous morphologies. In strains that maintained hyphal growth, treatment with carvacrol significantly reduced hyphal length. In addition, colonies grown in Spider medium supplemented with carvacrol exhibited predominantly smooth morphologies, with reduced filamentous formation. Lipase activity was also inhibited in all evaluated strains in the presence of the compound. Notably, variability in phenotypic response was observed among clinical isolates, particularly in strain 97, which maintained partial filamentation under treatment conditions.

conclusionsExposure to carvacrol was associated with alterations in morphogenesis- and lipase-associated phenotypes in clinical isolates of

Indexed as

antifungalfungal infectionlipasesmorphogenesisterpenes

Identifiers

PMID42506224
PMCPMC13412485

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.