Evidence map›Paper›PMID 42506066›Full record

ReviewJournal of personalized medicine2026

Intestinal Ultrasound-Guided Precision Medicine in Inflammatory Bowel Diseases: A Narrative Review.

Cicerone Clelia, Fabrizio Fanizzi, Arianna Dal Buono, Ilaria Faggiani, Ferdinando D'Amico, Alessandra Zilli, Tommaso Lorenzo Parigi, Virginia Solitano, Federica Furfaro, Sara Massironi and 3 more

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cicerone CleliaDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.ORCID 0009-0003-5400-2765
Fabrizio FanizziDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.ORCID 0009-0005-1198-6121
Arianna Dal BuonoIBD Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.ORCID 0000-0002-8543-4355
Ilaria FaggianiDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.ORCID 0009-0003-4501-6700
Ferdinando D'AmicoDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.ORCID 0000-0002-8591-6995
Alessandra ZilliDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.
Tommaso Lorenzo ParigiDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.
Virginia SolitanoDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.
Federica FurfaroFaculty of Medicine and Surgery, Vita e Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0002-4308-7295
Sara MassironiFaculty of Medicine and Surgery, Vita e Salute San Raffaele University, 20132 Milan, Italy.ORCID 0000-0003-3214-8192
Alessandro ArmuzziIBD Center, IRCCS Humanitas Research Hospital, Via Manzoni 56, 20089 Rozzano, Italy.ORCID 0000-0003-1572-0118
Silvio DaneseDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.
Mariangela AlloccaDepartment of Gastroenterology and Endoscopy, IRCCS Hospital San Raffaele, 20132 Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are characterized by marked heterogeneity, challenging disease monitoring and individualized treatment. Despite advances in treat-to-target strategies, unmet needs persist, particularly in assessing transmural healing and optimizing therapeutic decisions. This narrative review evaluates the role of intestinal ultrasound (IUS) as a key tool for precision medicine in IBD. IUS is a non-invasive, repeatable, and cost-effective imaging modality with diagnostic accuracy comparable to endoscopy and magnetic resonance enterography, with reported sensitivities and specificities frequently exceeding 80-90% for detecting active disease. It enables real-time assessment of transmural inflammation and complications, while parameters such as bowel wall thickness and Doppler vascularity support prognostic stratification. Early reductions in bowel wall thickness (≥25-30%) have been associated with improved treatment response, allowing identification of responders within weeks of therapy initiation. IUS informs therapeutic decision-making, including initiation, optimization, and de-escalation of advanced therapies, and may reduce reliance on invasive procedures. Integration into routine care has been associated with improved disease control and cost-effectiveness. Standardization of protocols, operator training, and prospective validation are required to establish IUS as a cornerstone of precision medicine in IBD.

Indexed as

IBDinflammatory bowel diseaseintestinal ultrasoundIUSpersonalized medicineprecision medicine

Identifiers

PMID42506066
PMCPMC13413011

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.