Evidence map›Paper›PMID 42505905›Full record

ArticleJournal of cardiovascular development and disease2026

Clinical and Economic Implications of High-Sensitivity Troponin-Informed Admission Strategies in Non-AMI Chest Pain.

Wanyi Chen, Allan S Jaffe, Fred S Apple, Christopher deFilippi, William Frank Peacock, Alan H B Wu, Rana Fayyad, Sarah Bethoney, Jingjing Zhang, Artem T Boltyenkov

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In one paragraph

Article in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wanyi ChenMedical Affairs, Siemens Healthcare Diagnostic Inc., Tarrytown, NY 10591, USA.
Allan S JaffeCardiovascular Department and Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1183-3959
Fred S AppleDepartment of Laboratory Medicine and Pathology, Hennepin Healthcare/Hennepin County Medical Center, Minneapolis, MN 55404, USA.
Christopher deFilippiSchool of Medicine, University of Maryland, Baltimore, MD 21201, USA.
William Frank PeacockEmergency Department, Ben Taub Hospital, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2730-6742
Alan H B WuDepartment of Laboratory Medicine, University of California, San Francisco, CA 94143, USA.
Rana FayyadMedical Affairs, Siemens Healthcare Diagnostic Inc., Tarrytown, NY 10591, USA.
Sarah BethoneyMedical Affairs, Siemens Healthcare Diagnostic Inc., Tarrytown, NY 10591, USA.ORCID 0009-0006-8425-7138
Jingjing ZhangMedical Affairs, Siemens Healthcare Diagnostic Inc., Tarrytown, NY 10591, USA.
Artem T BoltyenkovMedical Affairs, Siemens Healthcare Diagnostic Inc., Tarrytown, NY 10591, USA.ORCID 0000-0002-1143-5750

Funding

Siemens Healthineers (Germany) not applicable
6 · The paper itself

Abstract

Most patients with chest pain do not have acute myocardial infarction (AMI), yet post-AMI rule-out disposition remains variable. Detectable but sub-99th percentile high-sensitivity cardiac troponin I (hs-cTnI) provides additional prognostic information. We evaluated the economic value of hs-cTnI-guided hospitalizations among non-AMI patients. We analyzed 1481 non-AMI chest pain visits with detectable baseline hs-cTnI across 29 U.S. emergency departments (2014-2016) in the prospective HIGH-US trial using the Atellica IM TnIH assay(Siemens Healthcare Diagnostics, Tarrytown, NY, US). We compared observed standard-of-care admissions with modeled pathways incorporating hs-cTnI thresholds and risk scores, assessing admission rates, costs, and diagnostic accuracy for 30-day death/MI. Overall, 1.0% (

Indexed as

acute myocardial infarctionchest paineconomic evaluationhigh-sensitivity troponinprognostic value

Identifiers

PMID42505905
PMCPMC13409828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.