ReviewJournal of cardiovascular development and disease2026
Common Arterial Trunk with Intact Ventricular Septum: Morphologic and Developmental Considerations.
Review in Journal of cardiovascular development and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
backgroundIt is rare in clinical practice to encounter a common arterial trunk when the ventricular septum is intact. In this setting, other clinical diagnoses, such as hypoplastic left heart syndrome with aortic atresia, may be mistaken for a common arterial trunk. Data for this combination is largely limited to case reports and small case series. We have conducted a systematic review of reported cases, performing cluster analyses to provide an objective grouping of the cases.
methodsA systematic review of the literature was performed to identify cases of a common arterial trunk with an intact ventricular septum. Cases for which individual data were available were included in the final analyses. Cluster analysis using K-means clustering was conducted to provide an objective grouping of the hearts based on morphologic findings.
resultsK-means clustering identified three distinct groups among hearts with a common arterial trunk with intact ventricular septum. The commitment of the common ventriculo-arterial junction to the left, right, or both ventricles was the defining feature of each group. Hearts with a common trunk committed to one of the ventricles demonstrated significant hypoplasia or atresia of structures related to the other ventricle.
conclusionsDistinct patterns can be identified when a common arterial trunk is found with an intact ventricular septum. They depend on the ventricle or ventricles, which support the common ventriculo-arterial junction.
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