Identification of α6-Containing Nicotinic Acetylcholine Receptors as the Primary Target of Nereistoxin Insecticides and Structural Basis of Channel Blockade.

Licheng Gu, Yunxin Liang, Boyan Zhang, Jia Huang, Xiaomu Qiao

Abstract read

In one paragraph

Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Licheng GuCollaborative Innovation Center of Green Pesticide, National Joint Local Engineering Laboratory of Biopesticide Preparation, School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, China.ORCID 0009-0006-8453-1336

Yunxin LiangCollaborative Innovation Center of Green Pesticide, National Joint Local Engineering Laboratory of Biopesticide Preparation, School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, China.

Boyan ZhangMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.

Jia HuangMinistry of Agriculture Key Laboratory of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0001-8336-1562

Xiaomu QiaoCollaborative Innovation Center of Green Pesticide, National Joint Local Engineering Laboratory of Biopesticide Preparation, School of Forestry and Biotechnology, Zhejiang A & F University, Hangzhou 311300, China.ORCID 0000-0001-9590-1319

Funding

National Natural Science Foundation of China 32272571Zhejiang Provincial Natural Science Foundation LZ24C140003

6 · The paper itself

Abstract

Nereistoxin (NTX) and its derivative insecticides cartap and monosultap have been used for decades to control lepidopteran pests by targeting nicotinic acetylcholine receptors (nAChRs). Unlike neonicotinoid agonists that induce excitatory neurotoxicity, nereistoxin insecticides act as antagonists, blocking cholinergic neurotransmission. However, the molecular target and mechanism of action of these compounds remain incompletely understood. Here, we elucidated the mode of action of cartap and monosultap in

Indexed as

cartapDrosophila melanogastermolecular dockingmolecular targetnereistoxinnicotinic acetylcholine receptor

Identifiers

PMID42505854

DOI10.3390/insects17070743

PMCPMC13409772

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.