A FoxO-Autophagy-Lipid Mobilization Axis Regulates Fat Body Remodeling During Honeybee Metamorphosis.

Jing Yu, Hongfang Wang, Zhenguo Liu, Ying Wang, Baohua Xu

Abstract read

In one paragraph

Article in Insects, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jing YuCollege of Sports and Leisure, Shandong Sport University, Jinan 250102, China.

Hongfang WangCollege of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China.

Zhenguo LiuCollege of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China.

Ying WangCollege of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China.

Baohua XuCollege of Animal Science and Technology, Shandong Agricultural University, Taian 271000, China.

Funding

Earmarked Fund for China Agriculture Research System CARS-44National Natural Science Foundation of China No. 32272937Special Funds for the Efficient Ecological Agriculture Innovation Project of the Taishan Industry Leading Talent Program No. LJNY202003

6 · The paper itself

Abstract

Forkhead box O (FoxO) transcription factors act downstream of insulin signaling and play conserved roles in development and metabolic homeostasis in insects. However, whether FoxO participates in 20-hydroxyecdysone (20E)-mediated pupation and fat body remodeling in honeybee larvae remains unclear. Here, we show that FoxO is highly expressed during the prepupal and pupal stages of honeybee development. RNA interference (RNAi)-mediated silencing of FoxO delayed pupation, inhibited ecdysteroid biosynthesis and 20E signaling, and ultimately led to pupal lethality. Knockdown of FoxO also suppressed the expression of lipolytic genes, reduced lipase activity, and increased triglyceride (TG) accumulation in the fat body. Furthermore, FoxO deficiency impaired autophagy, as evidenced by reduced LysoTracker staining, decreased autophagosome formation, and downregulation of

Indexed as

Apis melliferaautophagyfat bodyFoxOlipolysis

Identifiers

PMID42505795

DOI10.3390/insects17070684

PMCPMC13410173

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.