ArticleDiseases (Basel, Switzerland)2026
Differential Respiratory Responses to Incremental Positive End-Expiratory Pressure Among Healthy Adults, Cigarette Smokers, Electronic Cigarette Users, and Individuals with Asthma.
Article in Diseases (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPositive end-expiratory pressure (PEEP) influences respiratory mechanics, ventilation distribution, and lung aeration. However, comparative responses to incremental PEEP among healthy individuals, cigarette smokers, electronic cigarette users, and individuals with asthma remain poorly understood. This study aimed to characterize differential respiratory responses to incremental PEEP across these populations.
methodsA secondary analysis was conducted using an open-access respiratory physiology dataset obtained from PhysioNet. Eighty adults were included and categorized into four groups (n = 20 per group): healthy controls, cigarette smokers, electronic cigarette users, and individuals with asthma. Airway pressure, respiratory flow, tidal volume, chest circumference, abdominal circumference, and global aeration were evaluated across incremental PEEP levels ranging from 4 to 12 cmH
resultsIncreasing PEEP significantly affected all respiratory and aeration outcomes (all
conclusionsIncremental PEEP significantly influenced respiratory mechanics, thoracoabdominal motion, and lung aeration. Respiratory responses differed among healthy controls, cigarette smokers, electronic cigarette users, and individuals with asthma, suggesting group-specific adaptations to increasing PEEP.
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