Evidence map›Paper›PMID 42505420›Full record

ArticleCells2026

TGFβ-Dependent Epithelial-Mesenchymal Plasticity in Immortalized Human Atrial Epicardial Cells: An mRNA Profiling Study.

Katja Nowak, René Schramm, Barbara Kaltschmidt, Christian Kaltschmidt, Cornelius Knabbe, Anna L Höving

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Katja NowakRuhr University Bochum, Heart and Diabetes Center NRW, Institute of Laboratory and Transfusion Medicine, 32545 Bad Oeynhausen, Germany.
René SchrammRuhr University Bochum, Heart and Diabetes Center NRW, Department of Thoracic and Cardiovascular Surgery, 32545 Bad Oeynhausen, Germany.
Barbara KaltschmidtUniversity Bielefeld, Faculty of Biology, Molecular Neurobiology, 33615 Bielefeld, Germany.
Christian KaltschmidtUniversity Bielefeld, Faculty of Biology, Department of Cell Biology, 33615 Bielefeld, Germany.
Cornelius KnabbeRuhr University Bochum, Heart and Diabetes Center NRW, Institute of Laboratory and Transfusion Medicine, 32545 Bad Oeynhausen, Germany.
Anna L HövingRuhr University Bochum, Heart and Diabetes Center NRW, Institute of Laboratory and Transfusion Medicine, 32545 Bad Oeynhausen, Germany.ORCID 0000-0002-5371-0220

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The adult mammalian heart exhibits limited regenerative capacity. Although the epicardium contributes to cardiac injury responses and remodeling, expandable adult human in vitro models for investigating epicardial activation and epithelial-to-mesenchymal (EMT)-associated cellular responses remain limited. Here, we isolated human epicardium-derived cells from the adult heart auricle, expressing WT1

Indexed as

Cell PlasticityEpithelial-Mesenchymal TransitionGene Expression ProfilingHeart AtriaPericardiumRNA, MessengerTransforming Growth Factor betaBenzamidesCell MovementDioxolesHumansSignal TransductionTransforming Growth Factor beta34-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideBenzamidesDioxolesRNA, MessengerTransforming Growth Factor betaTransforming Growth Factor beta3EMTepicardial activationepicardium-derived cellepithelial–mesenchymal plasticityepithelial-to-mesenchymal-transitionheart regeneration

Identifiers

PMID42505420
PMCPMC13406294

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.