Evidence map›Paper›PMID 42505419›Full record

ReviewCells2026

Pharmacological Targeting of Type H Endothelial Cells in Knee Osteoarthritis: From Molecular Signaling to Cellular Homeostasis.

Chunlu Yan, Chuangwei Sui, Qiao Wan, Xupeng Liu, Zeling Fang, Jiarong Shi, Chen Chen, Yu Jiang, Juan Yu, Fangyu An

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunlu YanDunhuang Medical Academy, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Chuangwei SuiSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.ORCID 0009-0005-4971-9977
Qiao WanSchool of traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Xupeng LiuSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Zeling FangSchool of traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Jiarong ShiSchool of traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Chen ChenSchool of traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Yu JiangSchool of Basic Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Juan YuSchool of Public Health, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Fangyu AnTeaching Experiment Training Center, Gansu University of Chinese Medicine, Lanzhou 730000, China.

Funding

Dingxi Science and Technology Plan Project DX2024BY017Gansu Joint Research Fund Project 24JRRA879Gansu Natural Science Foundation 24JRRA1026Graduate "Innovation and Entrepreneurship Fund" Project of Gansu University of Chinese Medicine 2026CXCY-212Graduate "Innovation and Entrepreneurship Fund" Project of Gansu University of Chinese Medicine 2026CXCY-236Higher Education Teaching Reform Research Project of Gansu Provincial GJJGB228The Education University Teachers' Innovation Fund Project of Gansu Provincial Education Department 2026B-118
6 · The paper itself

Abstract

The pathogenesis of knee osteoarthritis (KOA) involves bone homeostasis imbalance induced by inflammation, metabolism, age, mechanical stress, joint injury and other factors. Recently, Type H vessels (CD31

Indexed as

Endothelial CellsHomeostasisOsteoarthritis, KneeSignal TransductionAngiogenesisAnimalsHumansNeovascularization, Pathologiccell signalingknee osteoarthritissenolyticssmall molecule modulatorstype H endothelial cellsvascular–osteogenic coupling

Identifiers

PMID42505419
PMCPMC13407103

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.