ArticleCells2026
Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Is Required for Oligodendrocyte Maturation and Myelinogenesis in Mice.
Roxana Paula Ginerete, Roberta Facchinetti, Alessia Ceccherelli, Giada Mascio, Sara Rubio Casado, Luisa Di Menna, Sonia Castaldi, Matteo Caridi, Valeria Bruno, Ferdinando Nicoletti and 3 more
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Roxana Paula GinereteDepartment of Molecular Pathology, IRCCS Neuromed, 86077 Pozzilli, Italy.
Roberta FacchinettiDepartment of Life Science, Health, and Health Professions, Link Campus University, 00165 Roma, Italy.
Alessia CeccherelliDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University, 00185 Roma, Italy.ORCID 0000-0003-1461-0814 Giada MascioDepartment of Molecular Pathology, IRCCS Neuromed, 86077 Pozzilli, Italy.
Sara Rubio CasadoDepartment of Immunology, Ophthalmology and ORL, University Complutense, 28040 Madrid, Spain.ORCID 0000-0002-2020-2721 Sonia CastaldiDepartment of Molecular Pathology, IRCCS Neuromed, 86077 Pozzilli, Italy.
Matteo CaridiDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University, 00185 Roma, Italy.
Ferdinando NicolettiDepartment of Molecular Pathology, IRCCS Neuromed, 86077 Pozzilli, Italy.
Caterina ScuderiDepartment of Physiology and Pharmacology "V. Erspamer", Sapienza University, 00185 Roma, Italy.ORCID 0000-0002-7314-1539 Rosamaria OrlandoDepartment of Molecular Pathology, IRCCS Neuromed, 86077 Pozzilli, Italy.
Funding
Ministero della Salute Ricerca CorrenteSapienza University of Rome RM12117A8B314A71
6 · The paper itselfAbstract
mGlu5 metabotropic glutamate receptors are highly expressed and functional in early postnatal life, but their role in brain development remains to be elucidated. We now report that mGlu5
Indexed as
Myelin SheathOligodendrogliaReceptor, Metabotropic Glutamate 5AnimalsCell DifferentiationCerebellumCerebral CortexMiceMice, Inbred C57BLMice, KnockoutMyelin-Associated GlycoproteinMyelin Basic ProteinMyelin-Oligodendrocyte GlycoproteinRatsMyelin-Associated GlycoproteinMyelin Basic ProteinMyelin-Oligodendrocyte GlycoproteinReceptor, Metabotropic Glutamate 5mGlu5 receptorMTEPmyelinneurodevelopmentoligodendrocytes
Identifiers
PMID42505418
PMCPMC13406444
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