Evidence map›Paper›PMID 42505398›Full record

ReviewCells2026

Microtubule-Associated Proteins: From Dynamic Regulation of Microtubules to Cellular Architecture.

Eva Pais, Kenneth Bødtker Schou

Abstract readReview
In one paragraph

Review in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. International journal of molecular sciences · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Eva PaisDanish Cancer Institute, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.ORCID 0009-0001-9911-837X
Kenneth Bødtker SchouDanish Cancer Institute, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microtubule-associated proteins (MAPs) are key regulators of microtubule architecture and dynamics, orchestrating microtubule stability, post-translational modification, and spatial organization across diverse cellular contexts. Through these activities, MAPs govern essential processes including cell division, intracellular transport, signaling, and differentiation. This review synthesizes current insights into how MAPs regulate a diverse range of cellular processes, including maintenance of structural integrity, centriole assembly, cell division, the dynamic transition between centrosomal and ciliary states, and neuronal growth and connectivity. We discuss advances from structural biology, proteomics, and cell imaging that are redefining the molecular landscape of centriole and cilia regulation, and we highlight emerging themes linking MAP dysfunction to human disease, including cancer, ciliopathies, and neurodegenerative disorders. By integrating these diverse perspectives, the review outlines a unifying framework for understanding how MAPs orchestrate microtubule function and identifies key challenges and opportunities for future research.

Indexed as

Microtubule-Associated ProteinsMicrotubulesAnimalsCentriolesCiliaHumansMicrotubule-Associated Proteinsaxonemebasal bodiescentriolescentrosomeciliaciliogenesismicrotubule-associated proteinsmicrotubule inner proteinsmicrotubule outer proteinsmitotic spindle

Identifiers

PMID42505398
PMCPMC13406575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.