Evidence map›Paper›PMID 42505397›Full record

ArticleCells2026

Rasgrp1-Mediated Dampening of EGFR Signals Supports Coordinated Mammary Gland Development.

Alexandr Samocha, Lauren Shechtman, Eunice Bonfil Tapia, Hanna M Doh, Oghenekevwe Gbenedio, Vaishnavi Sitarama, Quy H Nguyen, Joshua D Rudolph, Walter L Eckalbar, Andrea J Barczak and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alexandr SamochaDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.
Lauren ShechtmanDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.ORCID 0000-0001-8376-3385
Eunice Bonfil TapiaDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.
Hanna M DohDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.ORCID 0000-0003-0781-611X
Oghenekevwe GbenedioDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.ORCID 0000-0002-5489-0067
Vaishnavi SitaramaDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.
Quy H NguyenDepartment of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA.ORCID 0000-0002-7016-1155
Joshua D RudolphUCSF Genomics CoLab, Lung Biology Center, School of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Walter L EckalbarUCSF Genomics CoLab, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Andrea J BarczakUCSF Genomics CoLab, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Yi MiaoDepartment of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Philippe DepeilleDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.
K Christopher GarciaDepartment of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
Devon A LawsonDepartment of Physiology and Biophysics, University of California Irvine, Irvine, CA 92697, USA.
Kai KessenbrockDepartment of Biological Chemistry, University of California Irvine, Irvine, CA 92697, USA.
Jeroen P RooseDepartment of Anatomy, University of California San Francisco, 513 Parnassus Avenue, Room HSW-1325, San Francisco, CA 94143, USA.ORCID 0000-0003-4746-2811

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHN KURIYAN · 2011 to 2026
$31.1M
TRANS-NETWORK PROJECTSU54CA143874 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI CHAKRABORTY, ARUP K. · 2009 to 2013
$15.1M
Structure-based Bioengineering of Wnt Surrogates for Intestinal Stem Cell Biology and TherapyR01DK115728 · NIDDK · STANFORD UNIVERSITY · PI GARCIA, KENAN CHRISTOPHER, KUO, CALVIN J · 2018 to 2022
$3.9M
Proteolytic regulation of Wnt signaling in breast cancer stem cellsR00CA181490 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KESSENBROCK, KAI · 2016 to 2018
$730k
Single-cell analysis of intratumor heterogeneity in metastasisK22CA190511 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAWSON, DEVON A. · 2016 to 2018
$486k
RAsGRP1 signals in breast development and cancerF31CA200342 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMOCHA, ALEXANDR · 2016 to 2017
$76k
CEK5--NOVEL TYROSINE KINASE AND POTENTIAL ONCOGENER01CA056721 · NCI · BURNHAM INSTITUTE FOR MEDICAL RESEARCH · PI PASQUALE, ELENA B · 1992 to 1994
–
Gabrielle's Angel Foundation for Cancer Research N/ANCI NIH HHS F31 CA200342NCI NIH HHS K22 CA190511NCI NIH HHS R00 CA181490NCI NIH HHS R01CA056721NCI NIH HHS U54 CA143874NIAID NIH HHS P01 AI091580NIDDK NIH HHS R01 DK115728NIH HHS 1F31CA200342-02NIH HHS 1K22CA190511-01NIH HHS 1P01AI091580-08NIH HHS 1R00CA181490-01NIH HHS 1R01DK115728-01NIH HHS 1U54CA143874-05The Mark Foundation for Cancer Research Cancer Research Momentum AwardUniversity of California, San Francisco ACS Grant ACS GrantUniversity of California, San Francisco Research Allocation Program (RAP) pilot grant Research Allocation Program (RAP) pilot grant
6 · The paper itself

Abstract

Mammary gland development during puberty requires tightly coordinated epithelial proliferation, lineage specification, and branching morphogenesis, processes critically regulated by growth factor signaling. While epidermal growth factor receptor (EGFR) signaling is essential for ductal development, how its activity is quantitatively controlled within mammary epithelial cells (MECs) remains incompletely understood. Here, we identify Rasgrp1, a Ras guanine nucleotide exchange factor, as a key modulator of EGFR signaling in the mammary epithelium. Using

Indexed as

DNA-Binding ProteinsErbB ReceptorsGuanine Nucleotide Exchange FactorsMammary Glands, AnimalSignal TransductionAnimalsCell ProliferationEpidermal Growth FactorEpithelial CellsFemaleHumansMechanistic Target of Rapamycin Complex 1MiceMorphogenesisOrganoidsPhosphatidylinositol 3-KinasesDNA-Binding ProteinsEGFR protein, mouseEpidermal Growth FactorErbB ReceptorsGuanine Nucleotide Exchange FactorsMechanistic Target of Rapamycin Complex 1Phosphatidylinositol 3-KinasesRasgrp1 protein, mousecell fateEGFRmammary glandorganoidPI3 kinaseRasGEFRasgrp1stem and progenitor cellsTEBtransplantation

Identifiers

PMID42505397
PMCPMC13406350

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.